{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:39:36Z","timestamp":1778229576148,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007252","name":"Baugarten Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00B\u2010114864"],"award-info":[{"award-number":["PP00B\u2010114864"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007214","name":"Velux Stiftung","doi-asserted-by":"publisher","award":["Grant Number 441"],"award-info":[{"award-number":["Grant Number 441"]}],"id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effect of daily 800 versus 2000\u2009IU of vitamin D3 supplementation over 24\u2009months on glycaemic control in older adults after unilateral knee replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients was a randomized, double\u2010blind trial conducted from 2008 to 2014 in Zurich, Switzerland. Participants were randomly allocated to 800 or 2000\u2009IU vitamin D3 daily for 24\u2009months. This study investigates the predefined secondary endpoints of fasting blood glucose (FBG) and homeostatic model assessment for insulin resistance (HOMA\u2010IR) using linear mixed models adjusted for age, sex, baseline vitamin D deficiency and body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 251 participants (age 70.2\u2009\u00b1\u20096.5\u2009years; 55.4% women; 39% impaired glucose tolerance, mean 25\u2010hydroxyvitamin D 27.48\u2009\u00b1\u200912.48\u2009ng\/mL, mean FBG 5.49\u2009\u00b1\u20090.71\u2009mmol\/L) were included in this analysis. There was no significant difference in FBG between the group receiving 800\u2009versus 2000\u2009IU after 2\u2009years with a least square mean (95% CI) of 5.32 (5.19; 5.44) versus 5.39 (5.27; 5.51) mmol\/L (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>treat<\/jats:italic>\n                      <\/jats:sub>\n                      =\u2009.130) and no difference in HOMA\u2010IR (0.44 [0.37; 0.52] vs. 0.49 [0.41; 0.58];\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>treat<\/jats:italic>\n                      <\/jats:sub>\n                      =\u2009.162), respectively. However, FBG decreased significantly over time independent of vitamin D3 dose (800\u2009IU: 5.54 [5.42; 5.66] to 5.32 [5.19; 5.44],\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>time<\/jats:italic>\n                      <\/jats:sub>\n                      &lt;\u2009.001; 2000\u2009IU: 5.5 [5.38; 5.62] to 5.39 [5.27; 5.51] mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>time<\/jats:italic>\n                      <\/jats:sub>\n                      =\u2009.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no clinically meaningful difference between 800 and 2000\u2009IU of vitamin D3 over 2\u2009years in FBG or HOMA\u2010IR in community\u2010dwelling older adults. Glycaemic outcomes improved in both groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14307","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T12:10:18Z","timestamp":1609157418000},"page":"1011-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of vitamin D3 on glucose metabolism in patients with severe osteoarthritis: A randomized double\u2010blind trial comparing daily 2000\u2009with 800 IU vitamin D3"],"prefix":"10.1111","volume":"23","author":[{"given":"Martin R.","family":"Gr\u00fcbler","sequence":"first","affiliation":[{"name":"Center on Aging and Mobility University Hospital Zurich, City Hospital Waid&amp;Triemli and University of Zurich  Zurich Switzerland"},{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism Medical University of Graz  Graz 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