{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:04:36Z","timestamp":1783382676196,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"NRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"MSIP","doi-asserted-by":"publisher","award":["NRF\u20102019R1A2C2007514"],"award-info":[{"award-number":["NRF\u20102019R1A2C2007514"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether degree of nonalcoholic fatty liver disease (NAFLD) is associated with myocardial dysfunction related to impaired myocardial glucose uptake in patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In total, 131 patients with type 2 diabetes from a tertiary care hospital were included in this study. Myocardial glucose uptake was assessed using [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010fluorodeoxyglucose\u2010positron emission tomography. Hepatic steatosis and fibrosis were determined using transient liver elastography. Echocardiography was performed to evaluate cardiac structure and function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with NAFLD had cardiac diastolic dysfunction with higher left ventricular filling pressure (E\/e' ratio) and left atrial (LA) volume index than patients without NAFLD (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Hepatic steatosis correlated with E\/e' ratio and LA volume index, and hepatic fibrosis also correlated with E\/e' ratio (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Even after adjusting for confounding factors, a higher degree of hepatic steatosis (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      = 0.409,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.041) and a higher degree of fibrosis (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      = 0.423,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009) were independent contributing factors to a higher E\/e' ratio. Decreased myocardial glucose uptake was associated with a higher degree of steatosis (\n                      <jats:italic>P<\/jats:italic>\n                      for trend = 0.084) and fibrosis (\n                      <jats:italic>P<\/jats:italic>\n                      for trend = 0.012). At the same time, decreased myocardial glucose uptake was an independent contributing factor for a higher E\/e' ratio (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      = 0.409;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hepatic steatosis and fibrosis were significantly associated with diastolic heart dysfunction in patients with type 2 diabetes coupled with impaired myocardial glucose uptake.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14310","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T13:39:50Z","timestamp":1609767590000},"page":"1041-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nonalcoholic fatty liver disease, diastolic dysfunction, and impaired myocardial glucose uptake in patients with type 2 diabetes"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-7512","authenticated-orcid":false,"given":"Minyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-8255","authenticated-orcid":false,"given":"Kwang Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University 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