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There is a growing body of evidence on the links between NAFLD\/NASH pathogenesis and mechanisms of metabolic dysfunction, through liver lipid accumulation, insulin resistance, inflammation, apoptosis, and fibrogenic remodelling within the liver. The frequent co\u2010occurrence of NAFLD with obesity, metabolic syndrome and type 2 diabetes supports this premise. Therapeutic approaches originally envisaged for type 2 diabetes or obesity (such as glucagon\u2010like peptide\u20101 receptor agonists, sodium\u2010glucose co\u2010transporter\u20102 inhibitors, insulin sensitizers and bariatric surgery) have shown promising signs of benefit for patients with NAFLD\/NASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the complex interplay between NAFLD and metabolic dysfunction, there is an urgent need for multidisciplinary collaboration and established protocols for care of patients with NAFLD that are individualized and ideally support reduction of overall metabolic risk as well as treatment for NASH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14322","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T12:44:18Z","timestamp":1611060258000},"page":"1069-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":174,"title":["<scp>Nonalcoholic fatty liver disease<\/scp>\n                    as a metabolic disease in humans: A literature review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-8040","authenticated-orcid":false,"given":"Bertrand","family":"Cariou","sequence":"first","affiliation":[{"name":"L'institut du Thorax, Department of Endocrinology UNIV Nantes, Inserm, CNRS, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Human Development and Health, Faculty of Medicine University of Southampton  Southampton UK"},{"name":"Southampton National Institute for Health Research, Biomedical Research Centre, University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Loomba","sequence":"additional","affiliation":[{"name":"NAFLD Research Center, Division of Gastroenterology University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i42.15539"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29085"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12271"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.084"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i32.7236"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2018-000864"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000255"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-420"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1071"},{"key":"e_1_2_9_13_1","unstructured":"National Institute for Health and Care Excellence.Non\u2010alcoholic fatty liver disease (NAFLD): assessment and management.2016.https:\/\/www.nice.org.uk\/guidance\/ng49\/chapter\/Recommendations. 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