{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:29:06Z","timestamp":1773196146943,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007542","name":"Air Liquide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004719","name":"LifeScan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005913","name":"National Humanities Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association between routine use of dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors and the severity of coronavirus disease 2019 (COVID\u201019) infection in patient with type 2 diabetes in a large multicentric study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID\u201019 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7\u2009days of admission. Stabilized weights were computed for patients based on propensity score (DPP\u20104 inhibitors users vs. non\u2010users) and were used in multivariable logistic regression models to estimate the average treatment effect in the treated as inverse probability of treatment weighting (IPTW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred and ninety\u2010six participants were under DPP\u20104 inhibitors before admission to hospital (24.3%). The primary outcome occurred at similar rates in users and non\u2010users of DPP\u20104 inhibitors (27.7% vs. 28.6%;\n                      <jats:italic>p<\/jats:italic>\n                      = .68). In propensity analysis, the IPTW\u2010adjusted models showed no significant association between the use of DPP\u20104 inhibitors and the primary outcome by Day 7 (OR [95% CI]: 0.95 [0.77\u20131.17]) or Day 28 (OR [95% CI]: 0.96 [0.78\u20131.17]). Similar neutral findings were found between use of DPP\u20104 inhibitors and the risk of tracheal intubation and death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data support the safety of DPP\u20104 inhibitors for diabetes management during the COVID\u201019 pandemic and they should not be discontinued.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14324","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T20:51:37Z","timestamp":1612558297000},"page":"1162-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Use of dipeptidyl peptidase\u20104 inhibitors and prognosis of\n                    <scp>COVID<\/scp>\n                    \u201019 in hospitalized patients with type 2 diabetes: A propensity score analysis from the\n                    <scp>CORONADO<\/scp>\n                    study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-8363","authenticated-orcid":false,"given":"Ronan","family":"Roussel","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Endocrinologie, Diab\u00e9tologie et Nutrition, H\u00f4pital Bichat, Assistance Publique\u2010H\u00f4pitaux de Paris Centre de Recherche des Cordeliers, INSERM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-2296","authenticated-orcid":false,"given":"Patrice","family":"Darmon","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie, Maladies M\u00e9taboliques et Nutrition, H\u00f4pital de la Conception, Assistance Publique\u2010H\u00f4pitaux de Marseille INSERM, INRA, C2VN, Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-6132","authenticated-orcid":false,"given":"Matthieu","family":"Pichelin","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Endocrinologie, Diab\u00e9tologie et Nutrition, l'institut du thorax INSERM, CNRS, UNIV Nantes, CHU Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-9821","authenticated-orcid":false,"given":"Thomas","family":"Goronflot","sequence":"additional","affiliation":[{"name":"CIC\u2010EC 1413, Clinique des Donn\u00e9es, CHU de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawa","family":"Abouleka","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Endocrinologie, Diab\u00e9tologie et Nutrition, H\u00f4pital Bichat, Assistance Publique\u2010H\u00f4pitaux de Paris Centre de Recherche des Cordeliers, INSERM  Paris 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