{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:43:31Z","timestamp":1785473011336,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether the use of evogliptin, a novel dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i), was associated with an increased risk of cardiovascular events compared with glimepiride in patients with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based cohort study using South Korea's nationwide healthcare database from 1 January 2014 to 31 December 2018. We identified a base cohort of patients with T2D who newly initiated metformin monotherapy, from which we identified a study cohort of patients who either added or switched to glimepiride or DPP\u20104is (including evogliptin). Patients were followed up from initiation of DPP\u20104is or glimepiride until the earliest of either outcome occurrence or 31 December 2018. Our primary outcome was hospitalization or an emergency visit for cardiovascular events, a composite endpoint comprised of cerebrovascular events, heart failure, myocardial infarction, transient ischaemic attack, angina pectoris and revascularization procedures; secondary outcomes were the individual components of the primary outcome. A multivariable Cox proportional hazards model was used to estimate adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for the risk of study outcomes associated with evogliptin compared with glimepiride.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our base and study cohorts had 317,307 and 128,788 patients, respectively, of which 100,038 were DPP\u20104i users (2946 were evogliptin users) and 28,750 were glimepiride users within the study cohort. The median follow\u2010up was 195\u2009days for evogliptin and 113\u2009days for glimepiride users. Compared with glimepiride, evogliptin was associated with a reduced risk of the primary outcome (aHR 0.67, 95% CI 0.48\u20130.95) and cerebrovascular events (aHR 0.41, 95% CI 0.22\u20130.78) but showed non\u2010significant associations for myocardial infarction (aHR 0.63, 95% CI 0.27\u20131.46), heart failure (aHR 0.35, 95% CI 0.09\u20131.47), transient ischaemic attack (aHR 0.23, 95% CI 0.03\u20131.72) and angina pectoris (aHR 1.35, 95% CI 0.82\u20132.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings from this population\u2010based cohort study provide novel real\u2010world evidence that the use of evogliptin, compared with glimepiride, did not increase the risk of cardiovascular events, including cerebrovascular events, myocardial infarction, heart failure, transient ischaemic attack and angina pectoris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14330","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T08:39:13Z","timestamp":1611736753000},"page":"1232-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular safety of evogliptin in patients with type 2 diabetes: A nationwide cohort study"],"prefix":"10.1111","volume":"23","author":[{"given":"So\u2010Hee","family":"Park","sequence":"first","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Eol","family":"Jeong","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Sun","family":"Oh","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Mo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Beom","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":false,"given":"Ju\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, Samsung Advanced Institute for Health Sciences &amp; Technology Sungkyunkwan University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00389"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.183"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0033"},{"key":"e_1_2_10_5_1","unstructured":"Guidance for Industry on Diabetes Mellitus\u2010Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes.https:\/\/www.federalregister.gov\/documents\/2008\/12\/19\/E8\u201030086\/guidance\u2010for\u2010industry\u2010on\u2010diabetes\u2010mellitus\u2010evaluating\u2010cardiovascular\u2010risk\u2010in\u2010new\u2010antidiabetic. Accessed May 1 2020."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.05.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007213"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.208"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007638"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12906"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i610"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13652"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050214-013431"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0505-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12870"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12987"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14061"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.5.718"},{"key":"e_1_2_10_19_1","first-page":"19","volume-title":"Report of the Evaluation for Validity of Discharged Diagnoses in Korean Health Insurance database","author":"Park B","year":"2003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0595"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.623"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4888"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00271-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000457"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12116"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0308"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12704"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12314"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307684"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305889"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.146"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501352"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18269"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01931-y"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506115"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.13772"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1943"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm324"},{"key":"e_1_2_10_40_1","volume-title":"Essentials of Infectious Disease Epidemiology","author":"Magnus M","year":"2008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i13.1246"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0822-4"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2693"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3342"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:29:07Z","timestamp":1761874147000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/dom.14330"],"URL":"https:\/\/doi.org\/10.1111\/dom.14330","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14330\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14330\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"2020-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}