{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:34:49Z","timestamp":1792928089888,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the feasibility and acceptability of using liraglutide 3.0\u00a0mg daily in the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first episode psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A double\u2010blind, randomized, placebo\u2010controlled pilot trial took place in mental health centres and primary care within Southern Health NHS Foundation Trust. The participants were adults with schizophrenia, schizoaffective or first\u2010episode psychosis prescribed antipsychotic medication who were overweight or obese. The intervention was once\u2010daily subcutaneous liraglutide or placebo, titrated to 3.0\u00a0mg daily, for 6\u00a0months. The primary outcomes were recruitment, consent, retention and adherence. The secondary exploratory outcomes were weight, HbA1c and Brief Psychiatric Rating Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven hundred and ninety\u2010nine individuals were screened for eligibility. The most common reasons for exclusion were ineligibility (44%) and inability to make contact (28%). The acceptance rate, as a proportion of all eligible participants, was 12.2%. The most commonly stated reason why eligible candidates declined to participate related to the study\u2010specific medication and protocol (n\u00a0=\u00a050). Forty\u2010seven participants were randomized, with 79% completing the trial. Participants in the liraglutide arm lost a mean 5.7\u2009\u00b1\u20097.9\u00a0kg compared with no significant weight change in the placebo group (treatment difference\u2009\u22126.0\u00a0kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015). Body mass index, waist circumference and HbA1c were reduced in the intervention group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports the need for a larger randomized controlled trial to evaluate the use of liraglutide (maximum dose 3.0\u00a0mg daily) in the management of obesity in people with severe mental illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14334","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T20:52:39Z","timestamp":1612558359000},"page":"1262-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["The use of liraglutide 3.0\u00a0mg daily in the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first episode psychosis: Results of a pilot randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Clare A.","family":"Whicher","sequence":"first","affiliation":[{"name":"Southern Health NHS Foundation Trust, Research &amp; Development Dept. Tom Rudd Unit Moorgreen Hospital  West End Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-0975","authenticated-orcid":false,"given":"Hermione C.","family":"Price","sequence":"additional","affiliation":[{"name":"Southern Health NHS Foundation Trust, Research &amp; Development Dept. Tom Rudd Unit Moorgreen Hospital  West End Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Phiri","sequence":"additional","affiliation":[{"name":"Southern Health NHS Foundation Trust, Research &amp; Development Dept. 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