{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:04Z","timestamp":1772160124735,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obesity is highly prevalent worldwide, including among people with chronic kidney disease (CKD). The presence of severe and\/or end\u2010stage kidney disease complicates the treatment of obesity for several reasons, including restrictions on protein and fluid intake and renal excretion of several medications indicated for the treatment of obesity. The aim of this review is to assess the safety of intensive obesity treatments, such as very\u2010low\u2010energy diets (VLEDs), obesity pharmacotherapy and\/or bariatric surgery, in people with end\u2010stage kidney disease. A literature search was conducted to identify studies reporting safety outcomes for VLEDs, liraglutide, phentermine, phentermine\u2010topiramate, naltrexone\u2010bupropion and bariatric surgery in people with an estimated glomerular filtration rate of less than 30\u2009mL\/min\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    or on dialysis. Limited data were insufficient to recommend VLEDs but highlighted their potential efficacy and the need for close clinical and biochemical monitoring. There were no data regarding centrally acting obesity pharmacotherapy in this population, although some glucagon\u2010like peptide\u20101 analogues appear to safely induce weight loss at doses used for the treatment of type 2 diabetes. Some studies suggest an increased rate of complications of bariatric surgery in individuals with severe or end\u2010stage CKD. Further prospective evaluation of intensive obesity management in the growing population with obesity and severe, end\u2010stage and dialysis\u2010dependent CKD is required.\n                  <\/jats:p>","DOI":"10.1111\/dom.14409","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:37:38Z","timestamp":1619505458000},"page":"1733-1745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intensive management of obesity in people with severe chronic kidney disease: A review"],"prefix":"10.1111","volume":"23","author":[{"given":"Richard","family":"Song","sequence":"first","affiliation":[{"name":"Melbourne Medical School University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Medicine (Austin) University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Endocrinology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hecham","family":"Harb","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-1050","authenticated-orcid":false,"given":"Priya","family":"Sumithran","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Austin Health  Melbourne Victoria Australia"},{"name":"Department of Medicine (St Vincent's) University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32225-6"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organisation: Obesity and overweight.2020.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight. 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