{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:07:27Z","timestamp":1791630447790,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation United Kingdom","doi-asserted-by":"publisher","award":["2\u2010SRA\u20102018\u2010654\u2010M\u2010B"],"award-info":[{"award-number":["2\u2010SRA\u20102018\u2010654\u2010M\u2010B"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether a FiASP\u2010and\u2010pramlintide closed\u2010loop system has the potential to replace carbohydrate counting with a simple meal announcement (SMA) strategy (meal priming bolus without carbohydrate counting) without degrading glycaemic control compared with a FiASP closed\u2010loop system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a 24\u2010hour feasibility study comparing a FiASP system with full carbohydrate counting (FCC) with a FiASP\u2010and\u2010pramlintide system with SMA. We conducted a subsequent 12\u2010day outpatient pilot study comparing a FiASP\u2010and\u2010placebo system with FCC, a FiASP\u2010and\u2010pramlintide system with SMA, and a FiASP\u2010and\u2010placebo system with SMA. Basal\u2010bolus FiASP\u2010and\u2010pramlintide were delivered at a fixed ratio (1\u2009U:10\u2009\u03bcg). Glycaemic outcomes were measured, surveys evaluated gastrointestinal symptoms and diabetes distress, and participant interviews helped establish a preliminary coding framework to assess user experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven participants were included in the feasibility analysis. Time spent in 3.9\u201010\u2009mmol\/L was similar between both interventions (81%\u201084%). Four participants were included in the pilot analysis. Time spent in 3.9\u201010\u2009mmol\/L was similar between the FiASP\u2010and\u2010placebo with FCC and FiASP\u2010and\u2010pramlintide with SMA interventions (70%), but was lower in the FiASP\u2010and\u2010placebo with SMA intervention (60%). Time\u2009less than 3.9\u2009mmol\/L and gastrointestinal symptoms were similar across all interventions. Emotional distress was moderate at baseline, after the FiASP\u2010and\u2010placebo with FCC and SMA interventions, and fell after the FiASP\u2010and\u2010pramlintide with SMA intervention. SMA reportedly afforded participants flexibility and reduced mealtime concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FiASP\u2010and\u2010pramlintide system has the potential to substitute carbohydrate counting with SMA without degrading glucose control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14447","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T08:43:57Z","timestamp":1622191437000},"page":"2090-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Alleviating carbohydrate counting with a\n                    <scp>FiASP\u2010plus\u2010pramlintide closed\u2010loop<\/scp>\n                    delivery system (artificial pancreas): Feasibility and pilot studies"],"prefix":"10.1111","volume":"23","author":[{"given":"Michael A.","family":"Tsoukas","sequence":"first","affiliation":[{"name":"Division of Endocrinology McGill University Health Centre  Montreal Canada"},{"name":"The Research Institute of McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Legault","sequence":"additional","affiliation":[{"name":"The Research Institute of McGill University Health Centre  Montreal Canada"},{"name":"Department of Pediatrics, Division of Pediatric Endocrinology McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"von Oettingen","sequence":"additional","affiliation":[{"name":"The Research Institute of McGill University Health Centre  Montreal Canada"},{"name":"Department of Pediatrics, Division of Pediatric Endocrinology McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-9050","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Yale","sequence":"additional","affiliation":[{"name":"Division of Endocrinology McGill University Health Centre  Montreal Canada"},{"name":"The Research Institute of McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vallis","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Dalhousie University  Halifax Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Odabassian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering McGill University  Montreal 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