{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:12:10Z","timestamp":1791727930762,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. The dual sodium\u2010glucose co\u2010transporter 1\/2 inhibitor (SGLT1\/2i) licogliflozin (LIK066) ameliorates hyperinsulinism in patients with diabetes and obesity. This study examines the effect of licogliflozin on androgens in women with PCOS. In a multicentre, randomized, placebo\u2010controlled, double\u2010blind, 2\u2010week trial, patients with PCOS received licogliflozin 50\u2009mg or placebo three times a day (TID). Changes in free testosterone (FT), other androgens and variables of insulin resistance were analysed. Concentration of FT did not change (TR\n                    <jats:sub>LIK066<\/jats:sub>\n                    :TR\n                    <jats:sub>PCB<\/jats:sub>\n                    [FT]: 0.88; 90% CI: 0.70\u20101.11;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.353). Licogliflozin reduced androstendione (A4) by 19% (TR\n                    <jats:sub>LIK066<\/jats:sub>\n                    :TR\n                    <jats:sub>PCB<\/jats:sub>\n                    [A4]: 0.81; 90% CI: 0.68\u20100.99;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.089) and dehydroepiandrosteron sulphate (DHEAS) by 24% (TR\n                    <jats:sub>LIK066<\/jats:sub>\n                    :TR\n                    <jats:sub>PCB<\/jats:sub>\n                    [DHEAS]: 0.76; 90% CI: 0.65\u20100.89;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.008). Hyperinsulinaemia was reduced by 70% by licogliflozin (highest insulin concentration [MAXI]; TR\n                    <jats:sub>LIK066<\/jats:sub>\n                    :TR\n                    <jats:sub>PCB<\/jats:sub>\n                    [MAXI]: 0\u00b726; 90% CI:0.20\u20100.34;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001 and area under the curve insulin [AUCI]; TR\n                    <jats:sub>LIK066<\/jats:sub>\n                    :TR\n                    <jats:sub>PCB<\/jats:sub>\n                    [AUCI]: 0.32; 90% CI: 0.25\u20100.41;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Diarrhoea and nausea occurred as common adverse events. Dual inhibition of SGLT1\/2 ameliorates hyperinsulinaemia and hyperandrogenaemia in women with PCOS. Licogliflozin may represent a promising novel treatment option for PCOS.\n                  <\/jats:p>","DOI":"10.1111\/dom.14495","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T06:50:29Z","timestamp":1626331829000},"page":"2595-2599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double\u2010blind, phase 2 trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-8643","authenticated-orcid":false,"given":"Susanne","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Ignatenko","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Research Organisation GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Wagner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Research Organisation GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Dokras","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Penn Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-7310","authenticated-orcid":false,"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Zwanziger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Dunschen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Translational Medicine  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Huseinovic","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Translational Medicine  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig T.","family":"Basson","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Translational Medicine  Cambridge Massachusetts USA"},{"name":"Boston Pharmaceuticals  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Mahling","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Translational Medicine  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Fuhrer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-8342","authenticated-orcid":false,"given":"Markus","family":"Hinder","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Translational Medicine  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3908"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4306-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4669-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13968"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13654"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.250"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-013-0030-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00286.2014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3399"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3285"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0832-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0294"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02985.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32202-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.018"}],"container-title":["Diabetes, Obesity and 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