{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:28:29Z","timestamp":1791584909255,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008276","name":"Per Henriksens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To test the hypothesis that treatment with liraglutide can reduce cardiac adipose tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>LIRAFLAME is a randomized placebo\u2010controlled, double\u2010blind, parallel clinical study. Participants with type 2 diabetes were randomized to treatment with liraglutide 1.8\u00a0mg\/d or placebo for 26\u2009weeks. Computed tomography was performed at baseline and at end of treatment to evaluate the cardiac adipose tissue volume, quantified automatically. We report the results of a secondary endpoint evaluating changes in cardiac adipose tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 102 participants were randomly assigned to liraglutide (n\u00a0=\u00a051) or placebo (n\u00a0=\u00a051). At baseline, the mean (SD) cardiac adipose tissue volume was comparable between the liraglutide and the placebo group (232.6 [112.8] vs. 227.0 [103.2] mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.80). The mean change in body weight was \u22123.7 (\u22124.8, \u22122.6) kg in the liraglutide and \u22120.18 (\u22120.76, 0.40) kg in the placebo group. From baseline to end of treatment the mean cardiac adipose tissue change was \u221211.5 (95% confidence interval \u221217.6, \u22125.4) mL in the liraglutide (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001) and \u22120.01 (\u22125.3, 5.3) mL in the placebo (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20091.00) groups. The reduction in cardiac adipose tissue was significantly greater in the liraglutide compared to the placebo group (mean difference \u221211.4 [\u221219.4, \u22123.3] mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.006), but significance was lost after adjustment for changes in body mass index (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.46).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with liraglutide for 26\u2009weeks was associated with a reduction in cardiac adipose tissue compared to placebo. The reduction was not independent of weight loss, suggesting that this is not a drug\u2010specific effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14516","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T06:21:30Z","timestamp":1628835690000},"page":"2651-2659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Liraglutide reduces cardiac adipose tissue in type 2 diabetes: A secondary analysis of the\n                    <scp>LIRAFLAME<\/scp>\n                    randomized\n                    <scp>placebo\u2010controlled<\/scp>\n                    trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-763X","authenticated-orcid":false,"given":"Ida K. B.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Steno Diabetes Centre Copenhagen  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-7070","authenticated-orcid":false,"given":"Emilie H.","family":"Zobel","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus S.","family":"Ripa","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET and Cluster for Molecular Imaging Rigshospitalet  Kobenhavn Denmark"},{"name":"University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernt J.","family":"von Scholten","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen  Gentofte Denmark"},{"name":"Novo Nordisk A\/S  S\u00f8borg 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