{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:28:26Z","timestamp":1792798106589,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the health outcomes associated with weight loss in individuals with obesity, and to better understand the relationship between disease burden (disease burden; ie, prior comorbidities, healthcare utilization) and weight loss in individuals with obesity by analysing electronic health records (EHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a case\u2010control study using deidentified EHR\u2010derived information from 204\u2009921 patients seen at the Cleveland Clinic between 2000 and 2018. Patients were aged \u226520\u2009years with body mass index \u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and had \u22657 weight measurements, over \u22653\u2009years. Thirty outcomes were investigated, including chronic and acute diseases, as well as psychological and metabolic disorders. Weight change was investigated 3, 5 and 10\u2009years prior to an event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Weight loss was associated with reduced incidence of many outcomes (eg, type 2 diabetes, nonalcoholic steatohepatitis\/nonalcoholic fatty liver disease, obstructive sleep apnoea, hypertension;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.05). Weight loss &gt;10% was associated with increased incidence of certain outcomes including stroke and substance abuse. However, many outcomes that increased with weight loss were attenuated by disease burden adjustments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the most comprehensive real\u2010world evaluation of the health impacts of weight change to date. After comorbidity burden and healthcare utilization adjustments, weight loss was associated with an overall reduction in risk of many adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14538","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:38:26Z","timestamp":1630564706000},"page":"2804-2813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Associations of weight loss with obesity\u2010related comorbidities in a large integrated health system"],"prefix":"10.1111","volume":"23","author":[{"given":"Arshiya","family":"Mariam","sequence":"first","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen","family":"Miller\u2010Atkins","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-4551","authenticated-orcid":false,"given":"Kevin M.","family":"Pantalone","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Iyer","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita D.","family":"Misra\u2010Hebert","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Internal Medicine, Cleveland Clinic Community Care Cleveland Clinic  Cleveland Ohio USA"},{"name":"Healthcare Delivery and Implementation Science Center Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Milinovich","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Bauman","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Mocarski","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilasha","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-3858","authenticated-orcid":false,"given":"B. 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