{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:39:02Z","timestamp":1792132742838,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the safety and efficacy of canagliflozin in comparison to metformin in polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010centre, prospective, randomized open\u2010label (ratio 1:1) noninferiority trial was conducted at the Department of Endocrinology, Shanghai Tenth People's Hospital, between July 2019 and April 2021. Women aged 18 to 45\u2009years with PCOS and IR were enrolled and randomly assigned to either 100\u2009mg (n\u00a0=\u00a033) canagliflozin daily or 1500 to 2000\u2009mg metformin daily (n\u00a0=\u00a035) for 12\u2009weeks. The primary outcome was changes in homeostatic model assessment (HOMA)\u2010IR after 12\u2009weeks of treatment. The secondary outcomes included changes in anthropometric measurements, menstrual frequency, sex hormone levels, metabolic variables and body fat distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For lowering of HOMA\u2010IR after 12\u2009weeks of treatment, canagliflozin was found to be noninferior to metformin (least\u2010squares mean difference \u22120.81% [95% confidence interval \u22122.13 to 0.51]). Both canagliflozin and metformin significantly improved menstrual pattern, reduced body weight and total fat mass, and decreased triglyceride levels. Compared with metformin, canagliflozin had significant advantages in reducing uric acid and dehydroepiandrosterone sulphate levels. Pruritus vulvae (9.09%) and gastrointestinal reaction (55.55%) were the main adverse events in the metformin group and canagliflozin group, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that canagliflozin was not inferior to metformin in PCOS patients with IR, which suggests that sodium\u2010glucose cotransporter\u20102 inhibitors should be considered as effective drugs in the treatment of PCOS patients with IR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14583","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T06:12:58Z","timestamp":1635833578000},"page":"312-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, 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