{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:08Z","timestamp":1772160128303,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017008","name":"Cancer Research UK Manchester Centre","doi-asserted-by":"publisher","award":["C147\/A18083"],"award-info":[{"award-number":["C147\/A18083"]}],"id":[{"id":"10.13039\/501100017008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017008","name":"Cancer Research UK Manchester Centre","doi-asserted-by":"publisher","award":["C147\/A25254"],"award-info":[{"award-number":["C147\/A25254"]}],"id":[{"id":"10.13039\/501100017008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the relationship between body mass index (BMI) and cancer mortality in incident type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the Clinical Practice Research Datalink GOLD (1998\u20102015), linked with the Office of National Statistics mortalities, and derived an incident type 2 diabetes cohort (N\u00a0=\u00a0176\u2009886; aged 30\u201085\u2009years). We determined BMI \u00b112\u2009months diabetes diagnosis. The primary outcome was cancer mortality, categorized into deaths from obesity\u2010related cancers (ORCs) and non\u2010ORCs. Secondary outcomes were site\u2010specific cancer mortality and main causes of deaths [cancer, cardiovascular disease (CVD), non\u2010cancer non\u2010CVD]. We developed gender\u2010specific Cox models and expressed risk as hazard ratios and 95% confidence intervals, stratified by smoking status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With 886\u2009850 person\u2010years follow\u2010up, 7593 cancer deaths occurred. Among women who never smoked, there were positive associations between BMI and deaths from endometrial (hazard ratios per 5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : 1.43; 95% confidence interval 1.26\u20101.61). Among men, associations between BMI and ORC mortality were inverse but attenuated towards null among never smokers and excluding deaths in the first 2\u2009years. In men, the proportion of CVD deaths increased from 36.8% in BMI category 22.5 to 24.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      to 43.6% in BMI category \u226540\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found some relationships between BMI and cancer mortality in patients with type 2 diabetes, but interpretations need to account for smoking status, reverse causality and deaths from CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14614","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T04:21:11Z","timestamp":1638764471000},"page":"620-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Body mass index and cancer mortality in patients with incident type 2 diabetes: A population\u2010based study of adults in England"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-9928","authenticated-orcid":false,"given":"Nasra N.","family":"Alam","sequence":"first","affiliation":[{"name":"Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-8332","authenticated-orcid":false,"given":"Alison 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