{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:58:30Z","timestamp":1787504310033,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007740","name":"Deutsche Dystonie Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the prevalence of elevated liver enzymes and associated diabetes\u2010related comorbidities in type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Between 2010 and 2019, 281 245 patients with T2D (aged 18\u201075\u2009years) from 501 Diabetes Prospective Follow\u2010up (DPV) centres were evaluated, resulting in analysis of 51\u2009645 patients with complete data on demographics and liver enzymes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated liver enzymes were found in 40.2% of all patients. However, only 8.6% of these patients had International Classification of Diseases\u201010 codes for nonalcoholic fatty liver disease and\/or nonalcoholic steatohepatitis. Adjusted for age, sex, diabetes duration, body mass index and glycated haemoglobin, a higher prevalence of arterial hypertension (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), dyslipidaemia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), peripheral artery disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0029), myocardial infarction (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0003), coronary artery disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0001), microalbuminuria (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and chronic kidney disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) was seen in patients with elevated versus normal liver enzymes. The prevalence of elevated liver enzymes was lowest in patients receiving sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitors or a combination of SGLT2 inhibitors and glucagon\u2010like peptide\u20101 receptor agonists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated liver enzymes are common in patients with T2D and clearly correlate with a higher prevalence of clinically relevant comorbidities. Assessing liver enzymes should be standard clinical routine in T2D due to a possible predictive role for comorbidities and complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14616","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:06:34Z","timestamp":1639029994000},"page":"727-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Elevated liver enzymes and comorbidities in type 2 diabetes: A multicentre analysis of 51 645 patients from the Diabetes Prospective Follow\u2010up (\n                    <scp>DPV)<\/scp>\n                    database"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-7022","authenticated-orcid":false,"given":"Svenja","family":"Meyh\u00f6fer","sequence":"first","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"},{"name":"Department of Internal Medicine 1 Endocrinology and Diabetes, University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-3078","authenticated-orcid":false,"given":"Alexander J.","family":"Eckert","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research  Neuherberg Germany"},{"name":"Institute of Epidemiology and Medical Biometry ZIBMT, University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hummel","sequence":"additional","affiliation":[{"name":"Specialized Diabetes Practice  Rosenheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Laimer","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-6382","authenticated-orcid":false,"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research  Neuherberg Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Institute for Clinical Diabetology, German Diabetes Centre Leibniz Institute for Diabetes Research at Heinrich\u2010Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kress","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Vinzentius\u2010Krankenhaus  Landau 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