{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:30:39Z","timestamp":1791394239845,"version":"4.3.3"},"reference-count":143,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is associated with visceral obesity, insulin resistance, type 2 diabetes (T2D) and has been often considered as the hepatic expression of the metabolic syndrome (MetS). Epidemiological studies highlight a bidirectional relationship of NAFLD with T2D in which NAFLD increases the risk of incident T2D and T2D increases the risk of severe non\u2010alcoholic steatohepatitis (NASH) and liver fibrosis. Regarding the molecular determinants of NAFLD, we specifically focused in this review on adipocyte dysfunction as a key molecular link between visceral adipose tissue, MetS and NAFLD. Notably, the subcutaneous white adipose tissue expandability appears a critical adaptive buffering mechanism to prevent lipotoxicity and its related metabolic complications, such as NAFLD and T2D. There is a clinical challenge to consider therapeutic strategies targeting the metabolic dysfunction common to NASH and T2D pathogenesis. Strategies that promote significant and sustained weight loss (~10% of total body weight) such as metabolic and bariatric surgery or incretin\u2010based therapies (GLP\u20101 receptor agonists or dual GLP\u20101\/GIP or GLP\u20101\/glucagon receptor co\u2010agonists) are among the most efficient ones. In addition, insulin sensitizers such as PPAR\u03b3 (pioglitazone) and pan\u2010PPARs agonists (lanifibranor) have shown some beneficial effects on both NASH and liver fibrosis. Since NASH is a complex and multifactorial disease, it is conceivable that targeting different pathways, not only insulin resistance but also inflammation and fibrotic processes, is required to achieve NASH resolution.<\/jats:p>","DOI":"10.1111\/dom.14651","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T03:35:50Z","timestamp":1641872150000},"page":"15-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The metabolic triad of non\u2010alcoholic fatty liver disease, visceral adiposity and type 2 diabetes: Implications for treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-8040","authenticated-orcid":false,"given":"Bertrand","family":"Cariou","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Nantes, Inserm, CNRS, CHU Nantes, l'institut du thorax  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14322"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.04.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029349"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1787"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13405"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008179"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13264"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1902"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26183"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1519"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221524"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24127"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12565"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.213553"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0012.0922"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003100"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1997"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.182"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.257"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0279"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323785111"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.039"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.12.018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1048"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101143"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2014.06.015"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00117.2003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05212.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22350"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.07.024"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002159"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2391"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1656"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21047"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23621"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904944106"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.90"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.056"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2576-y"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.4"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81507"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3714"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_7"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.12.8456"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2926-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.123"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.05.001"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7901"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00180.2018"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.9.2727"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.02.013"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.004"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32047"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.019"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78425"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.014"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00507-z"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003887"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093135"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.10.008"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212914"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.051"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.052"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15029"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.006"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173783"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101351"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311588"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2021.1951701"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12149"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13697"},{"issue":"2","key":"e_1_2_9_85_1","first-page":"407","article-title":"Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: the Lira\u2010NAFLD study","volume":"102","author":"Petit JM","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13487"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1937"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0697"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00274.2011"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.032"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.09.004"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.08.038"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1338"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0804"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01392-5"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.021"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i1.141"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12837"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32260-8"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107519"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1892"},{"key":"e_1_2_9_104_1","first-page":"1","article-title":"Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in patients with type 2 diabetes (SURPASS\u20103 MRI). 57th EASD Annual meeting. Abstract O426","volume":"64","author":"Gastaldelli A","year":"2021","journal-title":"Diabetologia"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30726-8"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0209-6"},{"key":"e_1_2_9_107_1","doi-asserted-by":"crossref","unstructured":"AbdelmalekMF ChoiJ HanO et al.2020.HM15211 a novel GLP\u20101\/GIP\/glucagon triple\u2010receptor co\u2010agonist significantly reduces liver fat and body weight in obese subjects with non\u2010alcoholic fatty liver disease: a phase 1b\/2a multicenter randomized placebo\u2010controlled trial. EASL ILC meeting 2020 (Poster).","DOI":"10.1016\/S0168-8278(20)30765-0"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2021.1947240"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.8.2169"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.135"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.03.001"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9607"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16583"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31843"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01285"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.025"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106170"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1589"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16596"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26461"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2012"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.038"},{"key":"e_1_2_9_124_1","unstructured":"Genfit Corp. GENFIT: Announces Results from Interim Analysis of RESOLVE\u2010IT Phase 3 Trial of Elafibranor in Adults with NASH and Fibrosis. 2020;https:\/\/ir.genfit.com\/news-releases\/news-release-details\/genfit-announces-results-interim-analysis-resolve-it-phase-3. Accessed 5 April 2021."},{"key":"e_1_2_9_125_1","unstructured":"CymaBay Therapeutics. CymaBay Therapeutics Halts Clinical Development of Seladelpar.2019;https:\/\/www.globenewswire.com\/newsrelease\/2019\/11\/25\/1951942\/0\/en\/CymaBay-Therapeutics-Halts-Clinical-Development-of-Seladelpar.html. Accessed 5 April 2021."},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12308"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1494153"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.023"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.154028"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.10.004"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.01.004"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0392"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.601290"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31785-9"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01425-3"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101152"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.01.008"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4675-2"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0165"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0641"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13584"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2009"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14304"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:12:55Z","timestamp":1761876775000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":143,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/dom.14651"],"URL":"https:\/\/doi.org\/10.1111\/dom.14651","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14651\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14651\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"2021-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}