{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:40:06Z","timestamp":1790314806673,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["NIH P30 DK036836"],"award-info":[{"award-number":["NIH P30 DK036836"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to examine the hypothesis that pramlintide would reduce hypoglycaemia by slowing gastric emptying and reducing postprandial glucagon secretion, thus limiting postprandial glycaemic excursions and insulin secretion, and thus to determine the efficacy of pramlintide on frequency and severity of hypoglycaemia in post\u2010bariatric hypoglycaemia (PBH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Participants with PBH following gastric bypass were recruited from outpatient clinics at the Joslin Diabetes Center, Boston, Massachusetts for an open\u2010label study of pramlintide efficacy over 8\u2009weeks. Twenty\u2010three participants were assessed for eligibility, 20 participants had at least one pramlintide dose, and 14 completed the study. A mixed\u2010meal tolerance test (MMTT) was performed at baseline and after 8\u2009weeks of subcutaneous pramlintide with a sequential dose increase to a maximum of 120 micrograms (mean 69\u2009\u00b1\u200932 mcg) three times daily. The primary endpoint was change in glucose excursions during the MMTT. Secondary measures included MMTT insulin response, satiety and dumping score, percentage time with sensor glucose (SG) &lt;3.9 mM, and number of days with minimum SG &lt;3 mM, during masked continuous glucose monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no differences in MMTT glucose, glucagon or insulin between baseline and post treatment. We observed no significant change in satiety or dumping scores. The overall frequency of low SG values did not change, although there was substantial inter\u2010individual variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In PBH, pramlintide does not modulate glycaemic or insulin responses, satiety, or dumping scores during an MMTT and does not impact glycaemic excursions or decrease low SG levels in the outpatient setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14665","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T01:53:33Z","timestamp":1644371613000},"page":"1021-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pramlintide for\n                    <scp>post\u2010bariatric<\/scp>\n                    hypoglycaemia"],"prefix":"10.1111","volume":"24","author":[{"given":"Amanda","family":"Sheehan","sequence":"first","affiliation":[{"name":"Research Division Joslin Diabetes Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Goldfine","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Wolfs","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center  Boston Massachusetts 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