{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:15:19Z","timestamp":1790630119926,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the feasibility of a prototype insulin infusion set (IIS) for extended wear in adults with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The prototype Capillary Biomedical investigational extended\u2010wear IIS (CBX IIS) incorporates a soft, flexible, reinforced kink\u2010resistant angled nylon\u2010derivative cannula with one distal and three proximal ports to optimize insulin delivery. Twenty adult participants with type 1 diabetes established on insulin pump therapy used the CBX IIS for two 7\u2010day test periods while wearing a Dexcom G5 continuous glucose monitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants were able to wear the CBX IIS for an average of 6.6\u2009\u00b1\u20091.4\u2009days. Eighty\u2010eight percent (36 of 41) of sets were worn for 7\u2009days. No serious adverse events were reported. Five infusion sets failed prematurely because of: unresolvable hyperglycaemia (three); hyperglycaemia with elevated ketones (one); or infection (one). Median time in range (3.9\u201010.0\u2009mmol\/L) was 62% (54\u201076). Average glucose levels per day of infusion set wear showed a statistically significant increase over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our preliminary observations confirm the tolerability of the prototype CBX IIS for extended wear, albeit with a deterioration in glucose control after the third day.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14685","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:01:11Z","timestamp":1646708471000},"page":"1143-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Feasibility study of a prototype extended\u2010wear insulin infusion set in adults with type 1 diabetes"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0821-3778","authenticated-orcid":false,"given":"Jasmin R.","family":"Kastner","sequence":"first","affiliation":[{"name":"Capillary Biomedical Inc.  Irvine California USA"},{"name":"The Artificial Pancreas Center, Department of Anesthesiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne, Department of Medicine, St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne, Department of Medicine, St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Muchmore","sequence":"additional","affiliation":[{"name":"Capillary Biomedical Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-395X","authenticated-orcid":false,"given":"Elif","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine Melbourne Medical School, University of Melbourne, Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Endocrinology and Diabetes The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Fourlanos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I","family":"Joseph","sequence":"additional","affiliation":[{"name":"Capillary Biomedical Inc.  Irvine California USA"},{"name":"The Artificial Pancreas Center, Department of Anesthesiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miami","family":"Shafeeq","sequence":"additional","affiliation":[{"name":"Capillary Biomedical Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Shi","sequence":"additional","affiliation":[{"name":"Integrated Medical Development, LLC  Princeton Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Strange","sequence":"additional","affiliation":[{"name":"Integrated Medical Development, LLC  Princeton Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Strasma","sequence":"additional","affiliation":[{"name":"Capillary Biomedical Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-4032","authenticated-orcid":false,"given":"David N.","family":"O'Neal","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne, Department of Medicine, St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0175"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/152091502320798312"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1205121"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071477"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400429"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0595"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0119"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815604438"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0445"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14395"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14337"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"IlanyJ CohenO KonvalinaN ZhangG&ChattarajSClinical Study of a New Extended Wear Infusion Set Design. Presented at Advanced Technologies & Treatments for Diabetes Conference 19\u201022 February 2020 Madrid Spain (2020). Diabetes Technology & Therapeutics.Feb 2020.A\u20101\u2010A\u2010250.https:\/\/doi.org\/10.1089\/dia.2020.2525.abstracts","DOI":"10.1089\/dia.2020.2525.abstracts"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296821999080"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"Buckingham B. A. Brazg R. L. Bailey T. S. Kudva Y. C. Garg S. K. Grunberger G. Thrasher J. Cavale A. Bhargaba A. Horowitz B. Kaiserman K. Huang S. Chen V. Zhang G. Chattaraj S. Shin J.&Vigersky R.100\u2010LB \u2013 infusion set survival and performance during the Medtronic extended\u2010wear infusion set (EWIS) pivotal trial. Presented at: American Diabetes Association Virtual 81st Scientific Sessions; June 25\u201029 2021; online (2021).","DOI":"10.2337\/db21-100-LB"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"Kastner J. R. 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