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Hepatic fat content was assessed by repeated abdominal magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Insulin clearance at fasting and during the OGTT was significantly increased after the diet, while body weight, glucose levels, absolute and glucose\u2010dependent insulin secretion, and model\u2010derived variables of \u03b2\u2010cell function were not affected. Dietary\u2010induced changes in insulin clearance positively correlated with changes in whole\u2010body insulin sensitivity and \u03b2\u2010cell glucose sensitivity, but not with changes in hepatic fat. Subjects with greater increases in insulin clearance showed a worse metabolic profile at enrolment, characterized by impaired insulin clearance, \u03b2\u2010cell glucose sensitivity, and glucose tolerance, and benefitted the most from the diet, achieving greater improvements in glucose\u2010stimulated hyperinsulinaemia, insulin resistance, and \u03b2\u2010cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed that a 12\u2010week low n\u20106:n\u20103 PUFA ratio diet improves hyperinsulinaemia by increasing fasting and postload insulin clearance in obese youth, independently of weight loss, glucose concentrations, and insulin secretion.<\/jats:p>\n                  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