{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:30:13Z","timestamp":1792161013483,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011946","name":"Abbott Diabetes Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Glycated haemoglobin (HbA1c) can fail to reflect average glucose levels, potentially compromising management decisions. We analysed variability in the relationship between mean glucose and HbA1c in individuals with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Three months of continuous glucose monitoring and HbA1c data were obtained from 216 individuals with type 1 diabetes. Universal red blood cell glucose transporter\u20101 Michaelis constant\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>M<\/jats:sub>\n                      and individualized apparent glycation ratio (AGR) were calculated and compared across age, racial and gender groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age (range) was 30\u2009years (8\u201072) with 94 younger than 19\u2009years, 78 between 19 and 50\u2009years, and 44 were &gt;50\u2009years. The group contained 120 women and 96 men with 106 white and 110 black individuals. The determined K\n                      <jats:sub>M<\/jats:sub>\n                      value was 464\u2009mg\/dl and AGR was (mean\u2009\u00b1\u2009SD) 72.1\u2009\u00b1\u20097\u2009ml\/g. AGR, which correlated with red blood cell lifespan marker, was highest in those aged &gt;50\u2009years at 75.4\u2009\u00b1\u20096.9\u2009ml\/g, decreasing to 73.2\u2009\u00b1\u20097.8\u2009ml\/g in 19\u201050\u2009years, with a further drop to 71.0\u2009\u00b1\u20095.8\u2009ml\/g in the youngest group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;0\u2009.05). AGR differed between white and black groups (69.9\u2009\u00b1\u20095.8 and 74.2\u2009\u00b1\u20097.1\u2009ml\/g, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). In contrast, AGR values were similar in men and women (71.5\u2009\u00b1\u20097.5 and 72.5\u2009\u00b1\u20096.6\u2009ml\/g, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.27). Interestingly, interindividual AGR variation within each group was at least four\u2010fold higher than average for between\u2010group variation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this type 1 diabetes cohort, ethnicity and age, but not gender, alter the HbA1c\u2010glucose relationship with even larger interindividual variations found within each group than between groups. Clinical application of personalized HbA1c\u2010glucose relationships has the potential to optimize glycaemic care in the population with diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14763","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T02:35:46Z","timestamp":1652322946000},"page":"1779-1787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interindividual variability in average\n                    <scp>glucose\u2010glycated haemoglobin<\/scp>\n                    relationship in type 1 diabetes and implications for clinical practice"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-8402","authenticated-orcid":false,"given":"Yongjin","family":"Xu","sequence":"first","affiliation":[{"name":"Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5584","authenticated-orcid":false,"given":"Richard M.","family":"Bergenstal","sequence":"additional","affiliation":[{"name":"International Diabetes Center Park Nicollet, HealthPartners  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashesvini","family":"Ram","sequence":"additional","affiliation":[{"name":"Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi A.","family":"Ajjan","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199912)41:4<540::AID-NEU9>3.0.CO;2-P"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0930"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154112"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0545"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1894"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz087"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14181"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1844"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00284"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.042"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42666-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105669"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-1973"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-5-201103010-00004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E685"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2596"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12696"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296819897613"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0553"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/14791641211013734"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69456"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2018.1480591"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0366-6"},{"key":"e_1_2_10_29_1","unstructured":"BrodksyRA.Diagnosis of hemolytic anemia in adults. 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