{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:15Z","timestamp":1787014095208,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the ability of ladarixin (LDX, 400\u2009mg twice\u2010daily for three\u2009cycles of 14\u2009days on\/14\u2009days off), an inhibitor of the CXCR1\/2 chemokine receptors, to maintain C\u2010peptide production in adult patients with newly diagnosed type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A double\u2010blind, randomized (2:1), placebo\u2010controlled study was conducted in 45 males and 31 females (aged 18\u201046\u2009years) within 100\u2009days of the first insulin administration. The primary endpoint was the area under the curve (AUC) for C\u2010peptide in response to a 2\u2010hour mixed meal tolerance test (AUC\n                      <jats:sub>[0\u2010120 min]<\/jats:sub>\n                      ) at week 13\u2009\u00b1\u20091. Secondary endpoints included C\u2010peptide AUC\n                      <jats:sub>(15\u2010120 min)<\/jats:sub>\n                      , HbA1c, daily insulin requirement, severe hypoglycaemic events (SHE), the proportion of subjects achieving HbA1c less than 7.0% without SHE and maintaining a residual beta cell function. Follow\u2010up assessments were scheduled at weeks 13\u2009\u00b1\u20091, 26\u2009\u00b1\u20092 and 52\u2009\u00b1\u20092.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 26\/26 (100%, placebo) and 49\/50 (98%, LDX) patients completed week 13. The mean change from baseline to week 13 in C\u2010peptide AUC\n                      <jats:sub>(0\u2010120 min)<\/jats:sub>\n                      was \u22120.144\u2009\u00b1\u20090.449\u2009nmol\/L with placebo and 0.003\u2009\u00b1\u2009.322\u2009nmol\/L with LDX. The difference was not significant (0.149\u2009nmol\/L, 95% CI \u22120.04 to 0.33;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.122). At week 26, the proportion of patients with HbA1c less than 7.0% without SHE was transiently higher in the LDX group (81% vs. 54%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.024). Otherwise, no significant secondary endpoint differences were noted. Transient metabolic benefit was seen at week 26 in favour of the LDX group in the prespecified subpopulation with fasting C\u2010peptide less than the median value at screening.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In newly diagnosed patients with type 1 diabetes, short\u2010term LDX treatment had no appreciable effect on preserving residual beta cell function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14770","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:35:43Z","timestamp":1653006943000},"page":"1840-1849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Ladarixin, an inhibitor of the interleukin\u20108 receptors\n                    <scp>CXCR1<\/scp>\n                    and\n                    <scp>CXCR2<\/scp>\n                    , in new\u2010onset type 1 diabetes: A multicentre, randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-2198","authenticated-orcid":false,"given":"Lorenzo","family":"Piemonti","sequence":"first","affiliation":[{"name":"IRCCS Ospedale San Raffaele and Universit\u00e0 Vita\u2010Salute Diabetes Research Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-4527","authenticated-orcid":false,"given":"Bart","family":"Keymeulen","sequence":"additional","affiliation":[{"name":"The Belgian Diabetes Registry, Academic Hospital and Diabetes Research Centre Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9111-4561","authenticated-orcid":false,"given":"Pieter","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven\u2010KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Linn","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Medical Clinic and Polyclinic III Center of Internal Medicine, Justus Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-2495","authenticated-orcid":false,"given":"Emanuele","family":"Bosi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele and Universit\u00e0 Vita\u2010Salute Diabetes Research Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Rose","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Diabetes und Gef\u00e4\u00dferkrankungen M\u00fcnster  Munster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-636X","authenticated-orcid":false,"given":"Paolo","family":"Pozzilli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases University Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-2678","authenticated-orcid":false,"given":"Francesco","family":"Giorgino","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efisio","family":"Cossu","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Daffonchio","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Goisis","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Adelchi","family":"Ruffini","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Maurizi","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Mantelli","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-0233","authenticated-orcid":false,"given":"Marcello","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Research and Development, Domp\u00e9 farmaceutici S.p.A  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30309-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05403-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2753-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043980"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904452"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60886-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0057"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70111-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902226"},{"key":"e_1_2_9_11_1","first-page":"1129","article-title":"Innate immunity mediated inflammation and beta cell function: neighbors or enemies?","volume":"11","author":"Citro A","year":"2020","journal-title":"Front Endocrinol."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0054"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60023-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9943"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12469"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1345"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122146"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3042"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0443"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01566.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026471"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.04.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502494"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00761.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1372"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2006136"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150074"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00019-X"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:58:31Z","timestamp":1761868711000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/dom.14770"],"URL":"https:\/\/doi.org\/10.1111\/dom.14770","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14770\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14770\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,4]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}