{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:38:48Z","timestamp":1761917928724,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011421","name":"Sanofi China Investment Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of basal insulin glargine 100\u2009units\/ml (Gla)\u2009+\u20092\u20103 oral antihyperglycaemic drugs (OADs) with twice\u2010daily premixed insulin aspart 70\/30 (Asp30)\u2009+\u2009metformin (MET) after short\u2010term intensive insulin therapy in adults with type 2 diabetes in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This open\u2010label trial enrolled insulin\u2010na\u00efve adults with type 2 diabetes and an HbA1c of 7.5%\u201011.0% (58\u201097\u2009mmol\/mol) despite treatment with 2\u20103 OADs. All participants stopped previous OADs except MET, then received short\u2010term intensive insulin therapy during the run\u2010in period, when those with a fasting plasma glucose of less than 7.0\u2009mmol\/L and 2\u2010hour postprandial glucose of less than 10.0\u2009mmol\/L were randomized to Gla\u2009+\u2009MET + a dipeptidyl peptidase\u20104 inhibitor or twice\u2010daily Asp30\u2009+\u2009MET. If HbA1c was more than 7.0% (&gt;53\u2009mmol\/mol) at week 12, participants in the Gla\u00a0group were added repaglinide or acarbose, at the physician's discretion, and participants in the Asp30 group continued to titrate insulin dose. The change in HbA1c from baseline to week 24 was assessed in the per protocol (PP) population (primary endpoint).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 384 enrollees (192 each to Gla and Asp30); 367 were included in the PP analysis. The threshold for non\u2010inferiority of Gla\u2009+\u2009OADs versus Asp30\u2009+\u2009MET was met, with a least squares mean change from baseline in HbA1c of \u20131.72% and \u20131.70% (\u201342.2 and \u201342.1\u2009mmol\/mol), respectively (estimated difference \u20130.01%; 95% CI \u20130.20%, 0.17% [\u20130.1\u2009mmol\/mol; 95% CI \u20132.2, 1.9]). Achievement of HbA1c less than 7.0% (&lt;53\u2009mmol\/mol) was comparable between the groups (60% vs. 57%). The proportion of participants with any (24% vs. 38%;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u00a0.003), symptomatic (19% vs. 31%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.007) or confirmed hypoglycaemia (18% vs. 33%;\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u00a0.001) was lower in the Gla\u2009+\u2009OADs group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with Asp30\u2009+\u2009MET, Gla + 2\u20103 OADs showed similar efficacy but a lower hypoglycaemia risk in Chinese individuals with type 2 diabetes who had undergone short\u2010term intensive insulin therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14780","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T04:00:13Z","timestamp":1654056013000},"page":"1957-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of a basal insulin + 2\u20103 oral antihyperglycaemic drugs regimen versus a twice\u2010daily premixed insulin + metformin regimen after short\u2010term intensive insulin therapy in individuals with type 2 diabetes: The multicentre, open\u2010label, randomized controlled\n                    <scp>BEYOND\u2010V<\/scp>\n                    trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Qi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Hospital National Center of Gerontology  Beijing 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