{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:03:42Z","timestamp":1781247822013,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000040"],"award-info":[{"award-number":["UL1TR000040"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F32DK113747"],"award-info":[{"award-number":["F32DK113747"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK063608"],"award-info":[{"award-number":["P30DK063608"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK26687"],"award-info":[{"award-number":["P30DK26687"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK098056"],"award-info":[{"award-number":["R01DK098056"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The contribution of endogenous glucagon\u2010like peptide (GLP)\u20101 to \u03b2\u2010cell function after Roux\u2010en\u2010Y gastric bypass surgery (RYGB) is well established in normoglycaemic individuals, but not in those with postoperative hyperglycaemia. We, therefore, studied the effect of GLP\u20101 on \u03b2\u2010cell function in individuals with varying degrees of type 2 diabetes mellitus (T2D) control after RYGB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Glucose, insulin secretion rates, \u03b2\u2010cell glucose sensitivity and glucagon were measured during an oral glucose tolerance test before (saline only) and at 3, 12 and 24\u2009months after RYGB with and without infusion of the GLP\u20101 receptor blocker exendin\n                      <jats:sub>9\u221239<\/jats:sub>\n                      (EX9). The cohort was retrospectively classified based on T2D remission (REM) status at the latest study time point: REM (n\u00a0=\u00a05), persistent T2D (n\u00a0=\u00a08), or impaired glucose tolerance (n\u00a0=\u00a016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EX9 blunted the increase in \u03b2\u2010cell glucose sensitivity at 3\u00a0months (\u221244.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and 12\u2009months (\u221243.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), but not at 24\u2009months (\u221212.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.243). EX9 enhanced postprandial glucagon concentrations by 62.0% at 3\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008), 46.5% at 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.055), and 30.4% at 24\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.017). EX9 counterintuitively decreased glucose concentrations at 3\u00a0months in the entire cohort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) but had no effect on glycaemia at 12 and 24\u2009months in persistent T2D and impaired glucose tolerance; it minimally worsened glycaemia in REM at 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 blockade reversed the improvement in \u03b2\u2010cell function observed after RYGB, but this effect varied temporally and by REM status. GLP\u20101 blockade transiently and minimally worsened glycaemia only in REM, and lowered postprandial glucose values at 3\u00a0months, regardless of REM status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14793","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T01:04:30Z","timestamp":1654736670000},"page":"2081-2089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Glucagon\u2010like peptide\u20101 effect on \u03b2\u2010cell function varies according to diabetes remission status after Roux\u2010en\u2010Y gastric bypass"],"prefix":"10.1111","volume":"24","author":[{"given":"Ankit","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Robert Wood Johnson Medical School Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Prasad","sequence":"additional","affiliation":[{"name":"New York Obesity Nutrition Research Center, Division of Endocrinology. 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