{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:48:26Z","timestamp":1790650106131,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011946","name":"Abbott Diabetes Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Flash glucose monitoring provides a range of glucose metrics. In the current study, we aim to identify those that indicate that glycaemic targets can be consistently met and contrast the total (t\u2010CV) and within\u2010day coefficient of variation (wd\u2010CV) to guide the assessment of glucose variability and hypoglycaemia exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>De\u2010identified data from Flash readers were collected. The readers were sorted into 10 equally sized groups of scan frequency followed by quartiles of estimated A1c (eA1c). A similar grouping was performed for the total coefficient of variation (t\u2010CV) and within\u2010day coefficient of variation (wd\u2010CV). In addition, analysis of the association of time below 54\u2009mg\/dl and glucose variability measured by t\u2010CV and wd\u2010CV was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dataset included 1\u00a0002\u2009946 readers. Readers sorted by 10 equal groups of scan rate and quartiles by eA1c, t\u2010CV and wd\u2010CV represented 25\u2009074 readers per group. The association of lower eA1c with higher time in range and reduced time above range was clear. The correlation of eA1c quartiles and time below range was not consistent. An association between glucose variability and hypoglycaemia was found. Both wd\u2010CV and t\u2010CV were associated with time below range. For achieving the consensus target of &lt;1% time below 54\u2009mg\/dl, the associated wd\u2010CV and t\u2010CV values were 33.5% and 39.5%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The type of CV reported by the different continuous glucose monitoring systems should be acknowledged. CV &lt;36% might not be adequate to ensure low hypoglycaemia exposure. To our knowledge, the majority of continuous glucose monitoring reports the t\u2010CV. Appropriate thresholds should be used to identify patients that would probably meet time below range targets (t\u2010CV &lt;40% or wd\u2010CV &lt;34%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14795","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T05:14:25Z","timestamp":1655097265000},"page":"2102-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Real world hypoglycaemia related to glucose variability and Flash glucose scan frequency assessed from global\n                    <scp>FreeStyle<\/scp>\n                    Libre data"],"prefix":"10.1111","volume":"24","author":[{"given":"Jean\u2010Pierre","family":"Riveline","sequence":"first","affiliation":[{"name":"Department of Diabetology and Endocrinology H\u00f4pital Lariboisi\u00e8re, APHP  Paris France"},{"name":"Unit\u00e9 INSERM U1138 Immunity and Metabolism in Diabetes, ImMeDiab Team Centre de Recherches des Cordeliers  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wojtusciszyn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, CHUV University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guerci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Nutrition Brabois Hospital, CHRU of Nancy &amp; University of Lorraine  Vandoeuvre\u2010L\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-8495","authenticated-orcid":false,"given":"Clara","family":"Alves","sequence":"additional","affiliation":[{"name":"Medical Affairs Abbott Diabetes Care  Delkenheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalvin","family":"Kao","sequence":"additional","affiliation":[{"name":"Clinical Affairs Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Affairs Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Clinical Affairs Abbott Diabetes Care  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30290-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010019\u201000741\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31535-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3805"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0255-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20100166"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20101690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19\u20100028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1659"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2012.0099"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1769"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20101847"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01577-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20101549"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:40:35Z","timestamp":1761885635000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/dom.14795"],"URL":"https:\/\/doi.org\/10.1111\/dom.14795","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14795\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14795\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}