{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:40:45Z","timestamp":1782909645491,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115881 (RHAPSODY)"],"award-info":[{"award-number":["115881 (RHAPSODY)"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016259","name":"Mylan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015268","name":"Solvay Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/13\/1\/30181"],"award-info":[{"award-number":["RE\/13\/1\/30181"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate the annual hospital costs associated with a range of adverse events for people with diabetes in the UK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Annual hospital costs (2019\/2020) were derived from 15\u2009436 ASCEND participants from 2005 to 2017 (120\u2009420 person\u2010years). The annual hospital costs associated with cardiovascular events (myocardial infarction, coronary revascularization, transient ischaemic attack [TIA], ischaemic stroke, heart failure), bleeding (gastrointestinal [GI] bleed, intracranial haemorrhage, other major bleed), cancer (GI tract cancer, non\u2010GI tract cancer), end\u2010stage renal disease (ESRD), lower limb amputation and death (vascular, non\u2010vascular) were estimated using a generalized linear model following adjustment for participants' sociodemographic and clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the year of event, ESRD was associated with the largest increase in annual hospital cost (\u00a320\u2009954), followed by lower limb amputation (\u00a317\u2009887), intracranial haemorrhage (\u00a312\u2009080), GI tract cancer (\u00a310\u2009160), coronary revascularization (\u00a38531 if urgent; \u00a38302 if non\u2010urgent), heart failure (\u00a38319), non\u2010GI tract cancer (\u00a37409), ischaemic stroke (\u00a37170), GI bleed (\u00a35557), myocardial infarction (\u00a34913), other major bleed (\u00a33825) and TIA (\u00a31523). In subsequent years, most adverse events were associated with lasting but smaller increases in hospital costs, except for ESRD, where the additional cost remained high (\u00a320\u2009090).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides robust estimates of annual hospital costs associated with a range of adverse events in people with diabetes that can inform future cost\u2010effectiveness analyses of diabetes interventions. It also highlights the potential cost savings that could be derived from prevention of these costly complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14796","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T01:05:30Z","timestamp":1654736730000},"page":"2108-2117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hospital costs associated with adverse events in people with diabetes in the\n                    <scp>UK<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-1706","authenticated-orcid":false,"given":"Mi Jun","family":"Keng","sequence":"first","affiliation":[{"name":"Health Economics Research Centre, Nuffield Department of Population Health University of Oxford  Oxford UK"},{"name":"British Heart Foundation Centre of Research Excellence  Oxford 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