{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:30:44Z","timestamp":1780479044463,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation United States of America","doi-asserted-by":"publisher","award":["3\u2010SRA\u20102015\u2010125\u2010M\u2010R"],"award-info":[{"award-number":["3\u2010SRA\u20102015\u2010125\u2010M\u2010R"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013845","name":"Pediatric Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TR001082"],"award-info":[{"award-number":["TR001082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1"],"award-info":[{"award-number":["UL1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the potential for glycaemic, renal and vascular benefits of bromocriptine quick release (BCQR) in adolescents and adults with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty adolescents and 40 adults with type 1 diabetes aged 12\u201060\u2009years old were enrolled in a double\u2010blind, placebo\u2010controlled, random order crossover study of 4\u2009weeks of treatment in the morning with BCQR (titrated weekly from 0.8\u00a0mg to 1.6\u00a0mg to 3.2\u00a0mg, minimum dose 1.6\u00a0mg). Study assessments after each phase included blood pressure (BP), lipids, peripheral arterial stiffness and autonomic function, mixed meal tolerance test, continuous glucose monitoring (CGM), creatinine, estimated glomerular filtration rate, estimated insulin sensitivity, insulin dose and indirect calorimetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adolescents displayed baseline hyperglycaemia, insulin resistance, metabolic dysfunction and increased renal filtration compared with adults. In both age groups, continuous glucose monitoring measures, estimated insulin sensitivity and insulin dose did not differ with BCQR treatment. In adolescents, BCQR decreased systolic BP, diastolic BP and triangular index and increased serum creatinine. In adults, systolic BP, mean arterial pressure, systemic vascular resistance, and mixed meal tolerance test glucose and glucagon\u2010like peptide 1 areas\u00a0under the curve were lower, and the orthostatic drop in systolic BP was greater with BCQR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater hyperglycaemia, insulin resistance, metabolic dysfunction and renal hyperfiltration in adolescents argues for increased attention during this high\u2010risk age period. Although BCQR had little impact on glycaemia or insulin sensitivity, initial vascular and renal responses suggest potential benefits of BCQR in adolescents and adults with type 1 diabetes requiring further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14800","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T02:44:04Z","timestamp":1655433844000},"page":"2148-2158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bromocriptine\n                    <scp>quick\u2010release<\/scp>\n                    as adjunct therapy in youth and adults with type 1 diabetes: A randomized,\n                    <scp>placebo\u2010controlled<\/scp>\n                    crossover study"],"prefix":"10.1111","volume":"24","author":[{"given":"Shoshana S.","family":"Tell","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Barbara Davis Center for Childhood Diabetes University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Schafer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Vigers","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado 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