{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:17:54Z","timestamp":1794071874646,"version":"4.8.0"},"reference-count":79,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of curcumin treatment on hepatic fat content in obese individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a double\u2010blind, parallel\u2010group trial, 37 obese, non\u2010diabetic individuals were randomized to placebo or curcumin treatment for 6\u2009weeks. Curcumin was dosed as lecithin\u2010formulated tablet; 200\u2009mg twice daily. The primary endpoint was hepatic fat content as assessed by magnetic resonance spectroscopy (MRS). Other endpoints included anthropometric measurements, hepatic biomarkers including FibroScan measurements, metabolic variables, inflammation markers, appetite measures and\n                      <jats:italic>ad libitum<\/jats:italic>\n                      food intake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics (mean\u2009\u00b1\u2009SD) were age 46\u2009\u00b1\u200914\u2009years, hepatic fat content 12.2%\u2009\u00b1\u20098.8% points, body mass index 38.8\u2009\u00b1\u20096.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and waist circumference 125.8\u2009\u00b1\u200912.3\u2009cm. After 6\u2009weeks of treatment with curcumin, hepatic fat content was changed by \u22120.86% points (95% CI\u00a0\u22123.65; 1.94) compared with 0.71% points (95% CI\u2009\u2212\u20092.08; 3.51) with placebo, thus resulting in a non\u2010significant estimated treatment difference of \u22121.57% points (95% CI\u2009\u22125.36; 2.22,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.412). Compared with placebo, curcumin treatment caused small reductions in fasting plasma glucose (estimated treatment difference [ETD]\u2009\u2212\u20090.24\u2009mmol\/L [95% CI\u2009\u22120.45; \u22120.03]), triglycerides (ETD [percentage change]\u2009\u221220.22% [95% CI\u2009\u221233.21; \u22126.03]) and gamma glutamyltransferase (ETD [percentage change]\u2009\u221215.70% [95% CI\u2009\u221223.32; \u22127.32]), but except for gamma glutamyltransferase, none of these differences remained statistically significant after adjusting for multiple testing. Treatment was well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with placebo, curcumin treatment for 6\u2009weeks had no significant effect on MRS\u2010assessed hepatic fat content in obese individuals with primarily mild steatosis. Curcumin was well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14804","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T06:56:43Z","timestamp":1656658603000},"page":"2192-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effect of curcumin on hepatic fat content in individuals with obesity"],"prefix":"10.1111","volume":"24","author":[{"given":"Pernille H.","family":"Hellmann","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan I.","family":"Bagger","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital 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