{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:49:35Z","timestamp":1792453775643,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Automated insulin delivery systems have improved glycaemic control in people with type 1 diabetes mellitus. The analysis investigated predictors of improved sensor glucose time\u2010in\u2010range (TIR; 70\u2010180\u2009mg\/dl) based on real\u2010world use of the MiniMed 780G advanced hybrid closed\u2010loop (AHCL) system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data uploaded by MiniMed 780G system users from August 2020\u2010July 2021 were analysed using univariate and multivariable models to identify baseline, demographic and system use characteristics associated with TIR after AHCL initiation (post\u2010AHCL). System settings associated with improved TIR post\u2010AHCL were identified and their impact on time below range (TBR, &lt;70\u2009mg\/dl) post\u2010AHCL was explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 12\u2009870 users were included, of which 2977 had baseline sensor glucose data. Baseline TIR and time in AHCL (defined as the percentage of time the system was in Auto\u2010mode) were positively associated with TIR post\u2010AHCL with larger values predicting greater mean TIR post\u2010AHCL. Characteristics inversely associated with TIR post\u2010AHCL included the percentage of daily basal insulin dose, daily autocorrection dose, number of daily AHCL exits triggered by the system and number of daily alarms, wherein larger values of these characteristics predicted lower mean TIR post\u2010AHCL. System settings that predicted the largest mean TIR post\u2010AHCL were active insulin time of 2\u2009h and glucose target of 100\u2009mg\/dl. Active insulin time was not associated with TBR post\u2010AHCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Modifiable factors, including optimized pump settings, can allow users to achieve glycaemic targets with &gt;80% TIR. The findings from this analysis will potentially guide the optimal use of the MiniMed 780G system and facilitate meaningful improvements in safe glycaemic control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14807","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T03:08:18Z","timestamp":1657076898000},"page":"2212-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Predictors of time in target glucose range in real\u2010world users of the\n                    <scp>MiniMed 780G<\/scp>\n                    system"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-8847","authenticated-orcid":false,"given":"Javier","family":"Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Medtronic Bakken Research Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-5233","authenticated-orcid":false,"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk\u2010Jan","family":"Aanstoot","sequence":"additional","affiliation":[{"name":"Diabeter, Center for Diabetes Care and Research  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcelia","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Medtronic International Trading S\u00e0rl  Tolochenaz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Shin","sequence":"additional","affiliation":[{"name":"Medtronic  Northridge California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-1795","authenticated-orcid":false,"given":"Ohad","family":"Cohen","sequence":"additional","affiliation":[{"name":"Medtronic International Trading S\u00e0rl  Tolochenaz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0203"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05391-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13567"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0319"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14424"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4314-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1674"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0455"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0384"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.07.024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0646"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0037"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01851-w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14714"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0349"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002187"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0202"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30230-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0246"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1549-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1072-2"},{"key":"e_1_2_10_26_1","unstructured":"MiniMed 780G System user guide.https:\/\/www.medtronic-diabetes.co.uk\/sites\/uk\/medtronic-diabetes.co.uk\/files\/pdf\/m003192c021doc_a_final_web_mm780g_ifu_mmol_compressed.pdf. 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