{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:48:42Z","timestamp":1788295722591,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The plant\u2010based polyphenol\u2010rich extract TOTUM\u201063 improves glucose homeostasis in various preclinical models of obesity and type 2 diabetes (T2D). A pilot exploratory study showed that TOTUM\u201063 has good safety and tolerability profiles, and beneficial effects on postprandial glucose control in healthy individuals with overweight. The aim of this study was to assess the effects of TOTUM\u201063 on glycaemic control in individuals with prediabetes or early stage newly\u2010diagnosed T2D (which does not require pharmacological treatment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study was a multicentre, randomized, double\u2010blind, placebo\u2010controlled trial. Individuals with prediabetes or early stage newly\u2010diagnosed T2D and with overweight\/abdominal obesity received TOTUM\u201063 (5\u2009g\/day) or placebo for 6\u2009months. The primary outcome was the change in fasting blood glucose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one participants (age: 57.1\u2009\u00b1\u200910\u2009years; body mass index: 31.3\u2009\u00b1\u20095.7\u00a0kg.m\n                      <jats:sup>2<\/jats:sup>\n                      ; 35 women and 16 men) completed the study (n\u00a0=\u00a038 TOTUM\u201063, n\u00a0=\u00a013 placebo). After 6\u00a0months, blood glucose concentration after fasting and after the 2\u2010h oral glucose tolerance test was reduced in the TOTUM\u201063\u2010treated group compared with the placebo group (placebo\u2010corrected difference between baseline and month 6: \u22120.71\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05, and \u22121.93\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05, respectively). TOTUM\u201063 was safe and well tolerated and significantly reduced body weight gain (\u22121.9\u00a0kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), waist circumference (\u22124.5\u00a0cm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), circulating triglycerides (\u22120.54\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and low\u2010density lipoprotein\u2010cholesterol (\u22120.38\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) compared with placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TOTUM\u201063 lowered fasting blood glucose in participants with impaired fasting glycaemia and glucose intolerance. Moreover, TOTUM\u201063 showed a good safety and tolerability profile and improved several metabolic syndrome features. Therefore, TOTUM\u201063 is a promising candidate for T2D prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14817","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T05:19:07Z","timestamp":1657862347000},"page":"2331-2340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>TOTUM<\/scp>\n                    \u201063, a plant\u2010based polyphenol\u2010rich extract, improves glycaemic control in subjects with prediabetes or early stage newly\u2010diagnosed type 2 diabetes in a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Pascal","family":"Sirvent","sequence":"first","affiliation":[{"name":"Valbiotis R&amp;D Center Valbiotis  Perigny 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