{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:24:32Z","timestamp":1790623472515,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["3U01DK057136\u201019S1 and 3; U01DK057136\u201019S2; U01DK0"],"award-info":[{"award-number":["3U01DK057136\u201019S1 and 3; U01DK057136\u201019S2; U01DK0"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG03308701; R01AG058571"],"award-info":[{"award-number":["R01AG03308701; R01AG058571"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether antihypertensive medication (AHM) acting through the renin angiotensin system (RAS\u2010AHM), compared with other AHM, can mitigate effects on cognitive function and risk for impairment in a population with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This secondary analysis of the randomized controlled Action for Health in Diabetes (Look AHEAD) study included 712 community\u2010dwelling participants who were followed over 15\u2009years. Logistic regression was used to relate RAS\u2010AHM use to cognitive impairment, and linear regression was used to relate RAS\u2010AHM use to domain\u2010specific cognitive function after adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 563 individuals reported RAS\u2010AHM use and 149 reported other\u2010AHM use during the study. RAS\u2010AHM users have college or higher education (53%), had higher baseline glycated haemoglobin (57 mmol\/mol), and reported higher diabetes medication use (86%), while other\u2010AHM users were more likely to be White (72%), obese (25%) and to have cardiovascular history (19%). RAS\u2010AHM use was not associated with a reduced risk of dementia compared with other\u2010AHM use. We did observe better executive function (Trail Making Test, part B,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.04), processing speed (Digit Symbol Substitution Test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.004), verbal memory (Rey Auditory Verbal Learning Test\u2010delayed recall,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.005), and composite score (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.008) among RAS\u2010AHM users compared with other\u2010AHM users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this sample of adults with T2DM, free of dementia at baseline, we observed a slower decline in processing speed, executive function, verbal memory, and composite score among RAS\u2010AHM users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14838","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T03:40:33Z","timestamp":1660621233000},"page":"2443-2453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of renin\u2010angiotensin system antihypertensive medication use on cognitive function in diabetes mellitus with obesity or overweight: An ancillary study to the Action for Health in Diabetes (Look\n                    <scp>AHEAD<\/scp>\n                    ) trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Whitney","family":"Wharton","sequence":"first","affiliation":[{"name":"Emory University School of Nursing  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of 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