{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:05Z","timestamp":1792012145436,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate the long\u2010term mortality and risk factors in patients with diabetic foot ulcer (DFU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched Medline (PubMed), Embase, Scopus, Web of Science, Cochrane Library, China Science and Technology Journal Database (CQVIP), China National Knowledge Infrastructure, the Chinese Biomedical Literature Database (SinoMed) and Wanfang Data from 1 January 2011 to 31 July 2022. All observational studies that reported long\u2010term mortality of patients with DFU were included. Random effect models were used to pool the reconstructed participant data from Kaplan\u2013Meier curves. The primary outcome was the long\u2010term survival of patients with DFU. An aggregate data meta\u2010analysis was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 34 studies, with 124\u2009376 participants representing 16 countries, among whom there were 51\u2009386 deaths. Of these, 27 studies with 21\u2009171 patients were included in the Kaplan\u2013Meier\u2010based meta\u2010analysis. The estimated Kaplan\u2013Meier\u2010based survival rates were 86.9% (95% confidence interval [CI] 82.6%\u201091.5%) at 1\u00a0year, 66.9% (95% CI 59.3%\u201075.6%) at 3\u2009years, 50.9% (95% CI 42.0%\u201061.7%) at 5\u2009years and 23.1% (95% CI 15.2%\u201034.9%) at 10\u2009years. The results of the aggregate data\u2010based meta\u2010analysis were similar. Cardiovascular disease and infection were the most common causes of death, accounting for 46.6% (95% CI 33.5%\u201059.7%) and 24.8% (95% CI 16.0%\u201033.5%), respectively. Patients with older age (per 1 year, hazard ratio [HR] 1.054, 95% CI 1.045\u20101.063), peripheral artery disease (HR 1.882, 95% CI 1.592\u20102.225), chronic kidney disease (HR 1.535, 95% CI 1.227\u20101.919), end\u2010stage renal disease (HR 3.586, 95% CI 1.333\u20109.643), amputation (HR 2.415, 95% CI 1.323\u20104.408) and history of cardiovascular disease (HR 1.449, 95% CI 1.276\u20101.645) had higher mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis found that the overall mortality of DFU was high, with nearly 50% mortality within 5\u2009years. Cardiovascular disease and infection were the two leading causes of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14840","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T03:56:43Z","timestamp":1660967803000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":256,"title":["Global mortality of diabetic foot ulcer: A systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"25","author":[{"given":"Lihong","family":"Chen","sequence":"first","affiliation":[{"name":"Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Innovation Center for Wound Repair, Diabetic Foot Care Center, 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