{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:21:49Z","timestamp":1761880909163,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014609","name":"Public Health Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007542","name":"Air Liquide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012151","name":"University Hospitals of Leicester NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006149","name":"Oxford University Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013963","name":"University Hospitals Birmingham NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000855","name":"University of Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003513","name":"University of Surrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011327","name":"Sandwell and West Birmingham Hospitals NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008979","name":"French Society of Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide a detailled analysis of the microvascular burden in patients with diabetes hopitalized for COVD\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We analysed data from the French CORONADO initiative and the UK Association of British Clinical Diabetologists (ABCD) COVID\u201019 audit, two nationwide multicentre studies, and the AMERICADO, a multicentre study conducted in New York area. We assessed the association between risk of all\u2010cause death during hospital stay and the following microvascular complications in patients with diabetes hospitalized for COVID\u201019: diabetic retinopathy and\/or diabetic kidney disease and\/or history of diabetic foot ulcer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2951 CORONADO, 3387 ABCD COVID\u201019 audit and 9327 AMERICADO participants, microvascular diabetic complications status was ascertained for 1314 (44.5%), 1809 (53.4%) and 7367 (79.0%) patients, respectively: 1010, 1059 and 1800, respectively, had \u22651 severe microvascular complication(s) and 304, 750 and 5567, respectively, were free of any complications. The patients with isolated diabetic kidney disease had an increased risk of all\u2010cause death during hospital stay: odds ratio [OR] 2.53 (95% confidence interval [CI] 1.66\u20103.83), OR 1.24 (95% CI 1.00\u20101.56) and OR 1.66 (95% CI 1.40\u20101.95) in the CORONADO, the ABCD COVID\u201019 national audit and the AMERICADO studies, respectively. After adjustment for age, sex, hypertension and cardiovascular disease (CVD), compared to those without microvascular complications, patients with microvascular complications had an increased risk of all\u2010cause death during hospital stay in the CORONADO, the ABCD COVID\u201019 diabetes national audit and the AMERICADO studies: adjusted OR (\n                      <jats:sub>adj<\/jats:sub>\n                      OR) 2.57 (95% CI 1.69\u20103.92),\n                      <jats:sub>adj<\/jats:sub>\n                      OR 1.22 (95% CI 1.00\u20101.52) and\n                      <jats:sub>adj<\/jats:sub>\n                      OR 1.33 (95% CI 1.15\u20101.53), respectively. In meta\u2010analysis of the three studies, compared to patients free of complications, those with microvascular complications had an unadjusted OR for all\u2010cause death during hospital stay of 2.05 (95% CI 1.42\u20102.97), which decreased to 1.62 (95% CI 1.19\u20102.119) after adjustment for age and sex, and to 1.50 (1.12\u20102.02) after hypertension and CVD were further added to the model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microvascular burden is associated with an increased risk of death in patients hospitalized for COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14845","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T04:14:58Z","timestamp":1660968898000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of microvascular complications with all\u2010cause death in patients with diabetes and\n                    <scp>COVID<\/scp>\n                    \u201019: The\n                    <scp>CORONADO<\/scp>\n                    ,\n                    <scp>ABCD<\/scp>\n                    COVID\u201019 UK national audit and\n                    <scp>AMERICADO<\/scp>\n                    study groups"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-6994","authenticated-orcid":false,"given":"Samy","family":"Hadjadj","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9 CHU Nantes, CNRS, Inserm, l'Institut du Thorax  Nantes 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 Manhasset New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Marre","sequence":"additional","affiliation":[{"name":"Clinique Ambroise Par\u00e9 Neuilly\u2010sur\u2010Seine, Centre de Recherches des Cordeliers Universit\u00e9 Paris Diderot  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Michel","family":"Halimi","sequence":"additional","affiliation":[{"name":"CHU de Tours, Service N\u00e9phrologie, Dialyse et Transplantation, Tours, France &amp; EA4245 Tours University  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Wargny","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9 CHU Nantes, CNRS, Inserm, l'Institut du Thorax  Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, P\u00f4le Hospitalo\u2010Universitaire 11: Sant\u00e9 Publique, Clinique des donn\u00e9es, INSERM  Nantes 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