{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:43:45Z","timestamp":1788381825481,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The voltage\u2010gated potassium channel K\n                      <jats:sub>v<\/jats:sub>\n                      11.1 is important for repolarizing the membrane potential in excitable cells such as myocytes, pancreatic \u03b1\u2010 and \u03b2\u2010cells. Moxifloxacin blocks the K\n                      <jats:sub>v<\/jats:sub>\n                      11.1 channel and increases the risk of hypoglycaemia in patients with diabetes. We investigated glucose regulation and secretion of glucoregulatory hormones in young people with and without moxifloxacin, a drug known to block the K\n                      <jats:sub>v<\/jats:sub>\n                      11.1 channel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The effect of moxifloxacin (800\u2009mg\/day for 4\u2009days) or placebo on glucose regulation was assessed in a randomized, double\u2010blind, crossover study of young men and women (age 20\u201040\u2009years and body mass index 18.5\u201027.5\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) without chronic disease, using 6\u2010h oral glucose tolerance tests and continuous glucose monitoring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight participants completed the study. Moxifloxacin prolonged the QTcF interval and increased heart rate. Hypoglycaemia was more frequently observed with moxifloxacin, both during the 8\u2009days of continuous glucose monitoring and during the oral glucose tolerance tests. Hypoglycaemia questionnaire scores were higher after intake of moxifloxacin. Moxifloxacin reduced the early plasma\u2010glucose response (AUC\n                      <jats:sub>0\u201030\u2009min<\/jats:sub>\n                      ) by 7% (95% CI: \u22129% to \u22124%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01), and overall insulin response (AUC\n                      <jats:sub>0\u2010360\u2009min<\/jats:sub>\n                      ) decreased by 18% (95% CI: \u221224% to \u221211%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and plasma glucagon increased by 17% (95% CI: 4%\u201033%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03). Insulin sensitivity calculated as the Matsuda index increased by 11%, and MISI, an index of muscle insulin sensitivity, increased by 34%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In young men and women, moxifloxacin, a drug known to block the K\n                      <jats:sub>v<\/jats:sub>\n                      11.1 channel, increased QT interval, decreased glucose levels and was associated with increased muscle insulin sensitivity and more frequent episodes of hypoglycaemia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14851","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T22:36:28Z","timestamp":1661553388000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A randomized, double\u2010blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-4017","authenticated-orcid":false,"given":"Christian R.","family":"Juhl","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-1081","authenticated-orcid":false,"given":"Josephine","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-8581","authenticated-orcid":false,"given":"Anniek F.","family":"Lubberding","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-3417","authenticated-orcid":false,"given":"Simon","family":"Veedfald","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1131","authenticated-orcid":false,"given":"Jonas L.","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2036","authenticated-orcid":false,"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-5027","authenticated-orcid":false,"given":"Ruth","family":"Frikke\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-9273","authenticated-orcid":false,"given":"Thomas","family":"Mandrup\u2010Poulsen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-4910","authenticated-orcid":false,"given":"J\u00f8rgen K.","family":"Kanters","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-0252","authenticated-orcid":false,"given":"Signe S.","family":"Torekov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7604285"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90340\u20102"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00\u20100077com"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.040659"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13781"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05\u20105350fje"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.048"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/11587800\u2010000000000\u201000000"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit439"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010019\u201000901\u20107"},{"key":"e_1_2_12_14_1","unstructured":"FDA.FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions.https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-updates-warnings-fluoroquinolone-antibiotics-risks-mental-health-and-low-blood-sugar-adverse.2018.https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-updates-warnings-fluoroquinolone-antibiotics-risks-mental-health-and-low-blood-sugar-adverse. Accessed March 7 2022."},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90358\u20105"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024279"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101454"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90839.2008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101879"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2000.36.4.570201"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4378"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32129\u20103"},{"key":"e_1_2_12_23_1","unstructured":"Danskernes sundhed Den Nationale Sundhedsprofil 2021.2022.www.sst.dk. Accessed March 28 2022."},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20102999(00)00693\u20102"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.1.122"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6741745"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/MCP.2000.111482"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216851"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1978244420"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/DIAB.43.4.535"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115012"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542\u2010474X.2003.08413.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169\u20102607(96)01755\u20105"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045858\u2010w"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.2517\u20106161.1995.TB02031.X"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706678"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab062"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010019\u20100220\u20103"},{"key":"e_1_2_12_41_1","unstructured":"Bethesda (MD).LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases."},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00394.2002"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPHAR.2004.06.032"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1476\u20105381.1996.TB15201.X"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCP.2008.11.019"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057841"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.11.011"},{"key":"e_1_2_12_48_1","first-page":"1","article-title":"Monitoring technologies\u2010continuous glucose monitoring, Mobile technology, biomarkers of glycemic control","volume":"16","author":"Reddy N","year":"2020","journal-title":"Endotext"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20102982.2001.00249.X"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:30:10Z","timestamp":1761877810000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/dom.14851"],"URL":"https:\/\/doi.org\/10.1111\/dom.14851","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14851\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"2022-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}