{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:13Z","timestamp":1772160133776,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of janagliflozin in Chinese patients with type 2 diabetes (T2D) inadequately controlled with metformin monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This multicentre phase 3 trial included a 24\u2010week, randomized, double\u2010blind, placebo\u2010controlled period, followed by a 28\u2010week extension period. Patients (N\u00a0=\u00a0421) with HbA1c\u2009of\u20097.0% or higher and\u200910.5% or less were randomized (1:1:1) to receive once\u2010daily placebo, janagliflozin 25 or 50\u2009mg. After the 24\u2010week treatment period, patients on placebo were re\u2010randomized (1:1) to janagliflozin 25\u2009or 50\u2009mg for the additional 28\u2010week treatment, whereas patients on janagliflozin maintained the same therapy. The primary endpoint was the change from baseline in HbA1c to week 24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 24, the placebo\u2010adjusted least squares mean changes of HbA1c were \u20130.58% and \u20130.58% with janagliflozin 25 and 50\u2009mg, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001 for both). The proportion of patients achieving HbA1c\u2009less than\u20097.0% was higher with janagliflozin 25 and 50\u2009mg compared with placebo (41.8%, 41.7% and 28.0%, respectively). Both janagliflozin doses provided significant reductions in fasting plasma glucose, 2\u2010hour postprandial glucose, body weight and systolic blood pressure, and improvements in high\u2010density lipoprotein cholesterol and insulin sensitivity compared with placebo (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05 for all). The trends in improvement of these variables were retained during the 28\u2010week extension period. No severe hypoglycaemia occurred throughout the whole 52\u2010week treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Janagliflozin 25\u2009or 50\u2009mg once\u2010daily added to metformin therapy significantly improved glycaemic control, reduced body weight and systolic blood pressure, improved high\u2010density lipoprotein cholesterol and insulin sensitivity, and was generally well\u2010tolerated by Chinese T2D patients who had poor glycaemic control with metformin monotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14926","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T09:28:11Z","timestamp":1669454891000},"page":"785-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of janagliflozin as add\u2010on therapy to metformin in Chinese patients with type 2 diabetes inadequately controlled with metformin alone: A multicentre, randomized, double\u2010blind, placebo\u2010controlled, phase 3 trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-9418","authenticated-orcid":false,"given":"Leili","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benli","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Hospital of Dalian Medical University  Dalian 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Endocrinology Jinan Central Hospital Affiliated to Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nanjing Jiangning Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second People's Hospital of Hefei  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Fourth Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The 2nd Affiliated Hospital of Harbin Medical University  Harbin 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