{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:45:34Z","timestamp":1776437134252,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825002"],"award-info":[{"award-number":["81825002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether intensive systolic blood pressure (SBP) lowering can benefit hypertensive patients with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed a pooled analysis of individual patient data from two randomized trials to compare intensive and standard SBP targets in hypertensive patients with diabetes (STEP diabetes subgroup and ACCORD\u2010BP standard glycaemic group, n\u00a0=\u00a01627 and n\u00a0=\u00a02362, respectively). We defined a modified primary outcome as a composite of stroke, major coronary artery disease (myocardial infarction and unstable angina), heart failure, and cardiovascular death. The secondary outcomes were individual components of the primary outcome and death from any cause. A Cox proportional hazards regression model was used in the main analysis. We conducted one\u2010stage mixed\u2010effect models and two\u2010stage analyses as sensitivity and supplementary analyses to verify the robustness of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3989 patients were randomized to undergo intensive (n\u00a0=\u00a01984) or standard SBP treatment (n\u00a0=\u00a02005). After a median follow\u2010up of 3.83\u2009years, the primary outcome occurred in 193\/1984 patients in the intensive group and in 247\/2005 patients in the standard group (hazard ratio [HR] 0.77, 95% confidence interval [CI] 0.64\u20100.93). The incidence rates for secondary outcomes were lower in the intensive group than in the standard group, but were not significantly different, except for stroke (intensive vs. standard: 32\/1984 vs. 58\/2005; HR 0.56, 95% CI 0.36\u20100.86). These results remained consistent in the additional sensitivity and supplementary analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An intensive SBP\u2010lowering target of 110 to &lt;130\u2009mmHg reduces the cardiovascular outcomes compared with a standard SBP\u2010lowering target of 130 to &lt;150\u2009mmHg. The findings of this study support the favourable effects of intensive SBP lowering in hypertensive patients with diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14927","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T09:53:59Z","timestamp":1669456439000},"page":"796-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of intensive blood pressure lowering in patients with diabetes: A pooled analysis of the\n                    <scp>STEP<\/scp>\n                    and\n                    <scp>ACCORD\u2010BP<\/scp>\n                    randomized trials"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-7765","authenticated-orcid":false,"given":"Ruixue","family":"Yang","sequence":"first","affiliation":[{"name":"Hypertension Center FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Bai","sequence":"additional","affiliation":[{"name":"Hypertension Center FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital National Center for Cardiovascular Diseases, Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Hospital of Kunming  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Chi","sequence":"additional","affiliation":[{"name":"Heart Center &amp; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Deng","sequence":"additional","affiliation":[{"name":"Hypertension Center 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