{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:15:53Z","timestamp":1788383753576,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the effectiveness and safety of early combination of insulin glargine with intravenous (IV) insulin infusion compared with IV insulin infusion alone in the management of diabetic ketoacidosis (DKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010centre, open\u2010label, randomized controlled trial of adults aged 18\u2009years or older diagnosed with DKA. The \u2018early glargine\u2019 group was given subcutaneous insulin glargine 0.3\u2009units\/kg within the first 3\u2009hours of DKA diagnosis, in addition to the standard IV insulin infusion. The control group received standard IV insulin treatment only. The primary outcome was the time to DKA resolution. The other outcomes included rebound hyperglycaemia, mortality, hypoglycaemia and hypokalaemia, as well as the length of hospital stay (LOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 60 patients (30 patients per group) were enrolled. Most patients (76.7%) had type 2 diabetes. Both groups were similar in baseline characteristics, except for higher serum beta\u2010hydroxybutyrate and lower pH levels in the early glargine group. The mean\u2009\u00b1\u2009standard deviation time to DKA resolution in the early glargine group was significantly faster than the control group (9.89\u2009\u00b1\u20093.81 vs. 12.73\u2009\u00b1\u20095.37\u2009hours;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.022). The median (interquartile range) LOS was significantly shorter in the early glargine group than in the control group (4.75 [3.53\u20108.96] vs. 15.25 [5.71\u201026.38] days;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.024). The incidence of rebound hyperglycaemia, all\u2010cause mortality, hypoglycaemia and hypokalaemia was similar between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early combination of insulin glargine with IV insulin infusion led to a faster DKA resolution and a shorter LOS, without increasing hypoglycaemia and hypokalaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14929","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T16:30:45Z","timestamp":1670430645000},"page":"815-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Kitti","family":"Thammakosol","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-8601","authenticated-orcid":false,"given":"Chutintorn","family":"Sriphrapradang","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1583"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016587"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1171-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-9916"},{"issue":"8","key":"e_1_2_9_8_1","first-page":"995","article-title":"Incidences and outcomes of hyperglycemic crises: a 5\u2010year study in a tertiary care center in Thailand","volume":"95","author":"Anthanont P","year":"2012","journal-title":"J Med Assoc Thai."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00922-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2019-0003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16376"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03246.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14788"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0674-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399817666210303095633"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12462"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1244"},{"issue":"5","key":"e_1_2_9_18_1","first-page":"OC01","article-title":"Effectiveness of insulin glargine on recovery of patients with diabetic ketoacidosis: a randomized controlled trial","volume":"9","author":"Houshyar J","year":"2015","journal-title":"J Clin Diagn Res."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12673"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0362"},{"issue":"6","key":"e_1_2_9_21_1","first-page":"761","article-title":"Systematic review with meta\u2010analysis: subcutaneous insulin glargine coadministration for diabetic ketoacidosis","volume":"152","author":"Andrade\u2010Castellanos CA","year":"2016","journal-title":"Gac Med Mex."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198510000-00009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00400"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2021.1341"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.5.644"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1258"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002451"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-017-0857-4"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:23:56Z","timestamp":1761891836000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/dom.14929"],"URL":"https:\/\/doi.org\/10.1111\/dom.14929","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14929\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14929\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}