{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:53:37Z","timestamp":1785840817055,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M18\u20100169"],"award-info":[{"award-number":["M18\u20100169"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M19\u20100266"],"award-info":[{"award-number":["M19\u20100266"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003186","name":"Fredrik och Ingrid Thurings Stiftelse","doi-asserted-by":"publisher","award":["2019\u201000488"],"award-info":[{"award-number":["2019\u201000488"]}],"id":[{"id":"10.13039\/501100003186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["P18\u20100084"],"award-info":[{"award-number":["P18\u20100084"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association between objective sleep parameters and glycaemic variability determined by continous glucose monitoring (CGM) among patients with type 2 diabetes, given the significant role of sleep in glycaemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, CGM was carried out in 28 patients with T2D (aged 62.3\u2009\u00b1\u20094.8\u2009years, 57% women). Sleep characteristics were assessed by actigraphy within the CGM period. CGM\u2010derived outcomes included glucose level, and percentages of time in range (TIR) and time above range (TAR) during the monitoring period. Associations between intraindividual night\u2010to\u2010night variations in sleep characteristics and overall CGM outcomes were analysed using linear regression. Associations between sleep characteristics during each night and time\u2010matched CGM outcomes were analysed using linear mixed models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 249 person\u2010days of CGM, coupled with 221 nights of sleep characteristics, were documented. Greater standard deviation (SD) of objective sleep duration (minutes) between measurement nights was associated with higher glucose level (coefficient 0.018\u2009mmol\/L [95% confidence interval {CI} 0.004, 0.033],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017), smaller proportion of TIR (% in observation period; coefficient \u22120.20% [95% CI \u22120.36, \u22120.03],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.023), and greater proportion of TAR (coefficient 0.22% [95% CI 0.06, 0.39],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011). Later sleep midpoint (minutes from midnight) was associated with greater SD of glucose during the same sleep period (coefficient 0.002 minutes [95% CI 0.0001, 0.003],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.037), longer nocturnal sleep duration was associated with smaller coefficient of variation of glucose level in the upcoming day (\u22120.015% [95% CI \u22120.03, \u22120.001],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Objectively determined sleep duration and sleep midpoint, as well as their daily variability, are associated with CGM\u2010derived glucose profiles in T2D patients.<\/jats:p>\n                  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