{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:31Z","timestamp":1793726071906,"version":"4.6.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["1030\u201000256B"],"award-info":[{"award-number":["1030\u201000256B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate changes in cardiac repolarisation during exercise\u2010related hypoglycaemia compared to hypoglycaemia induced at rest in people with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      In a randomised crossover study, 15 men with type 1 diabetes underwent two separate hyperinsulinaemic euglycaemic\u2010hypoglycaemic clamp experiments during Holter\u2010ECG monitoring. One experiment included a bout of moderate\u2010intensity cycling exercise (60\u2009min) along with declining plasma glucose (PG;\n                      <jats:italic>Clamp\u2010exercise<\/jats:italic>\n                      ). In the other experiment, hypoglycaemia was induced with the participants at rest (\n                      <jats:italic>Clamp\u2010rest<\/jats:italic>\n                      ). We studied QTc interval, T\u2010peak to T\u2010end (Tpe) interval and hormonal responses during three steady\u2010state phases: (i) baseline (PG 4.0\u20138.0\u2009mmol\/L); (ii) hypoglycaemic phase (PG\u2009&lt;3.0\u2009mmol\/L); and (iii) recovery phase (PG 4.0\u20138.0\u2009mmol\/L).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both QTc interval and Tpe interval increased significantly from baseline during the hypoglycaemic phase but with no significant difference between test days. These changes were accompanied by an increase in plasma adrenaline and a decrease in plasma potassium on both days. During the recovery phase, \u0394QTc interval was longer during\n                      <jats:italic>Clamp\u2010rest<\/jats:italic>\n                      compared to\n                      <jats:italic>Clamp\u2010exercise<\/jats:italic>\n                      , whereas \u0394Tpe interval remained similar on the two test days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that both exercise\u2010related hypoglycaemia and hypoglycaemia induced at rest can cause QTc\u2010interval prolongation and Tpe\u2010interval prolongation in people with type 1 diabetes. Thus, both scenarios may increase susceptibility to ventricular arrhythmias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14964","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:48:10Z","timestamp":1672706890000},"page":"1186-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exercise\u2010related hypoglycaemia induces\n                    <scp>QTc<\/scp>\n                    \u2010interval prolongation in individuals with type 1 diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-9010","authenticated-orcid":false,"given":"Per G.","family":"Hagelqvist","sequence":"first","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-5140","authenticated-orcid":false,"given":"Andreas","family":"Andersen","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-5719","authenticated-orcid":false,"given":"Kaisar B.","family":"Maytham","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-2644","authenticated-orcid":false,"given":"Christine R.","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-3455","authenticated-orcid":false,"given":"Susanne","family":"Engberg","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-2795","authenticated-orcid":false,"given":"Tommi B.","family":"Lindhardt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nordsj\u00e6llands Hospital Hiller\u00f8d, University of Copenhagen  Hiller\u00f8d Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-3772","authenticated-orcid":false,"given":"Jens","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Endocrinology Herlev Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0869","authenticated-orcid":false,"given":"Julie L.","family":"Forman","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Public Health Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-4880","authenticated-orcid":false,"given":"Ulrik","family":"Pedersen\u2010Bjergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Endocrinology and Nephrology Nordsj\u00e6llands Hospital Hiller\u00f8d, University of Copenhagen  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-5034","authenticated-orcid":false,"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-6787","authenticated-orcid":false,"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Clinical Research Copenhagen University Hospital, Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Center for Clinical Metabolic Research Gentofte Hospital, University of Copenhagen  Hellerup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-0612-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0354"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30315-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1177-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0253-y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.03.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.6.1469"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00283.2005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz891"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600430"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/21\/2\/309"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/6.suppl_D.81"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542-474X.2003.08413.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.32552\/2020.ActaMedica.493"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_10_17_1","first-page":"345","article-title":"QT interval prolongation during rapid fall in blood glucose in type I diabetes","volume":"34","author":"Christensen TF","year":"2007","journal-title":"Comput Cardiol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01123.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.7.1798"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.6.E908"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320314529356"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05361-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1535"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93774-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003264"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200602000-00009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00408.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13348"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.840568"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022147"},{"key":"e_1_2_10_31_1","unstructured":"AndreasenC AndersenA HagelqvistP LauritsenJ EngbergS HolstJ et al.235\u2010OR\u2010sustained QTc prolongation during recovery from hypoglycemia in patients with type 1 diabetes. Abstr 82nd ADA Annu Meet.2022."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun137"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2008.07.021"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000561"},{"key":"e_1_2_10_35_1","first-page":"353","article-title":"Flattening of the electrocardiographic T\u2010wave is a sign of proarrhythmic risk and a reflection of action potential triangulation","volume":"40","author":"Bhuiyan TA","year":"2013","journal-title":"Comput Cardiol"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.960658"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2177"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00208.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2004.04.006"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2022"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14964","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:54:40Z","timestamp":1761893680000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/dom.14964"],"URL":"https:\/\/doi.org\/10.1111\/dom.14964","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14964\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14964\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14964\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14964\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14964\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14964\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"assertion":[{"value":"2022-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}