{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:59:47Z","timestamp":1783958387838,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To present the results of an exploratory analysis of the BEYOND V study in which Chinese individuals with uncontrolled type 2 diabetes (T2D) received short\u2010term intensive insulin therapy (SIIT) during study run\u2010in (prior to randomization) using a basal\u2010first insulin titration method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This was exclusively an exploratory analysis of the 7\u2010 to 10\u2010day run\u2010in period of BEYOND V. Participants were hospitalized and had oral therapies withdrawn (except metformin). They received SIIT with once\u2010daily insulin glargine and three\u2010times\u2010daily premeal insulin glulisine, titrated daily from a total starting dose of 0.4 to 0.5\u00a0units\/kg\/d, first adjusting insulin glargine to achieve fasting blood glucose (FBG) of 4.4 to 6.1\u2009mmol\/L (79 to 119\u2009mg\/dL), then insulin glulisine to achieve pre\u2010meal blood glucose of 4.4 to 6.1\u2009mmol\/L. Key outcomes were the proportions of participants achieving FBG and 2\u2010hour postprandial blood glucose (PBG) targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 397 entered the run\u2010in (mean 54.2\u2009years, 235 males [59.2%]). At the end of SIIT, 374\/396 participants (94.4%) had both FBG &lt;7.0\u2009mmol\/L (&lt;126\u2009mg\/dL) and 2\u2010hour PBG &lt;10\u2009mmol\/L (&lt;180\u2009mg\/dL) and 282\/396 (71.2%) had both FBG &lt;6.1\u2009mmol\/L (&lt;100\u2009mg\/dL) and 2\u2010hour PBG &lt;10\u2009mmol\/L. The mean first time taken to achieve FBG &lt;7\u2009mmol\/L, 2\u2010hour PBG &lt;10\u2009mmol\/L, and both, was 4.35, 3.88, and 5.04\u2009days, respectively. Hypoglycaemia occurred in 99 participants (24.9%). There was no severe hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Titrating basal insulin first is an effective and safe method of SIIT in individuals with T2D, rapidly achieving target glucose levels with a relatively low rate of hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14970","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T07:49:11Z","timestamp":1672732151000},"page":"1221-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of\n                    <scp>basal\u2010first<\/scp>\n                    titration order in individuals with type 2 diabetes receiving\n                    <scp>short\u2010term<\/scp>\n                    intensive insulin therapy: An exploratory analysis of\n                    <scp>BEYOND V<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"given":"Yijun","family":"Li","sequence":"first","affiliation":[{"name":"The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongni","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-1798","authenticated-orcid":false,"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3540","authenticated-orcid":false,"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Wan","sequence":"additional","affiliation":[{"name":"Panjin Central Hospital  Panjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Harbin the First Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Baotou Medical College  Baotou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxia","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second People's Hospital of Yibin  Yibin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[{"name":"People's Hospital of Liaoning Province  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Department Sanofi Investment Co, Ltd.  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