{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:07:10Z","timestamp":1787677630573,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) is the leading cause of chronic kidney disease. Albuminuria is associated with an increased risk of cardiovascular mortality. Sodium\u2010glucose cotransporter 2 inhibitors (SGLT2\u2010Is) and mineralocorticoid receptor antagonists (MRAs) protect against albuminuria; however, their combined effects on albuminuria are unclear. We performed a network meta\u2010analysis to investigate the effects of SGLT2\u2010Is, MRAs and their combination on albuminuria in type 2 DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Medline, EMBASE and the Cochrane Library from inception up to 20 November 2022. We selected randomized control and crossover trials that compared MRAs, SGLT2\u2010Is, MRAs\u2009+\u2009SGLT2\u2010Is, or a placebo in patients with type 2 DM with a urinary albumin\u2010creatinine ratio (UACR) \u226530\u2009mg\/g creatinine. The primary outcome was the change in the UACR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This meta\u2010analysis analysed 17 studies with 34\u2009412 patients. The use of combination treatment with SGLT2\u2010Is and MRAs was associated with lower albuminuria compared with the use of SGLT2\u2010Is, MRAs, or the placebo alone [mean difference (95% CI): \u221234.19 (\u221227.30; \u221241.08), \u221232.25 (\u221224.53; \u221239.97) and \u221265.22 (\u221257.97; \u221272.47), respectively]. Treatment with SGLT2\u2010Is or MRAs alone caused a significant reduction in UACR compared with the placebo [mean difference (95% CI): \u221231.03 (\u221228.35; \u221233.72) and \u221232.97 (\u221229.68; \u221236.27), respectively]. The effects of MRAs on the UACR are comparable with those of SGLT2\u2010Is. Sensitivity analyses showed similar results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combination therapy with SGLT2\u2010Is and MRAs was associated with lower albuminuria in patients with type 2 DM compared with monotherapy with SGLT2\u2010Is or MRAs alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14976","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T09:50:08Z","timestamp":1673517008000},"page":"1271-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of sodium\u2010glucose cotransporter 2 inhibitors, mineralocorticoid receptor antagonists, and their combination on albuminuria in diabetic patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Ryutaro","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Medicine Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai  New York New York 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