{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:17:08Z","timestamp":1780093028825,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1111\/dom.14984","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:44:01Z","timestamp":1674553441000},"page":"940-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral insulin: A history of ambition, failure and data torturing"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-2037","authenticated-orcid":false,"given":"Tim","family":"Heise","sequence":"first","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona","family":"Plum\u2010M\u00f6rschel","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-5452","authenticated-orcid":false,"given":"Eric","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3286.1204"},{"key":"e_1_2_5_3_1","first-page":"144","volume-title":"Frontiers in Insulin Pharmacology","author":"Berger M","year":"1993"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00182-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0053-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1807"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814529988"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105812"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.730"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01576"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30372-3"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17487-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00772-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-021-01025-x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau2277"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.522"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14901"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14922"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03631-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01146.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.02941.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14499"},{"key":"e_1_2_5_23_1","unstructured":"Oramed Pharmaceuticals Inc.Oramed Announces Top\u2010Line Results from Phase 3 Trial of ORMD\u20100801 for the Treatment of Type 2 Diabetes. Oramed Pharmaceuticals Inc.2023.https:\/\/oramed.com\/oramed-announces-top-line-results-from-phase-3-trial-of-ormd-0801-for-the-treatment-of-type-2-diabetes\/Accessed 19 January 2023."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291613"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12609"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:46:42Z","timestamp":1761875202000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/dom.14984"],"URL":"https:\/\/doi.org\/10.1111\/dom.14984","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14984\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14984\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]},"assertion":[{"value":"2022-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}