{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:55:05Z","timestamp":1781654105976,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700299"],"award-info":[{"award-number":["81700299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To perform a meta\u2010analysis to assess the effects of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) on major coronary events, including myocardial infarction (MI), unstable angina and coronary revascularization, in patients with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We systematically searched the PubMed, CENTRAL, EMBASE and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">clinicaltrial.gov<\/jats:ext-link>\n                      databases to seek eligible studies with a cardiovascular endpoint comparing GLP\u20101RAs with a placebo in T2DM patients. Odds ratio (ORs) and 95% confidence intervals (CIs) were calculated for the outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine studies, with a total of 64\u2009236 patients, were included. GLP\u20101RA treatment reduced fatal and nonfatal MI by 8% (OR 0.92, 95% CI 0.86\u20130.99;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200939%). The reduction reached 15% in human\u2010based GLP\u20101RA\u2010treated patients. Similarly, once\u2010weekly GLP\u20101RA treatment reduced the risk of MI by 13%. In contrast, GLP\u20101RA treatment did not reduce the risk of hospitalization for unstable angina (OR 1.11, 95% CI 0.97\u20131.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.13,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a021%). GLP\u20101RAs exhibited a tendency to lower the risk of coronary revascularization (OR 0.95, 95% CI 0.89\u20131.02;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.15,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a022%), but without statistical significance. Human\u2010based GLP\u20101RAs decreased the risk by 11%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In high\u2010risk patients with T2DM, GLP\u20101RAs were associated with a decrease in MI, especially the human\u2010based and once\u2010weekly GLP\u20101RAs. No benefit was seen for hospitalization for unstable angina or coronary revascularization. Further research is urgently needed to ascertain improvements in coronary events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15043","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:34:25Z","timestamp":1677803665000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of glucagon\u2010like peptide\u20101 receptor agonists on major coronary events in patients with type 2 diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-1387","authenticated-orcid":false,"given":"Xueyuan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases  Beijing 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