{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:59:17Z","timestamp":1793293157543,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceutical Company","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of a novel sodium\u2010glucose cotransporter 2 inhibitor, enavogliflozin 0.3\u00a0mg monotherapy, in Korean people with type 2 diabetes mellitus (T2DM) inadequately controlled with diet and exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study was a randomized, double\u2010blind, placebo\u2010controlled trial conducted in 23 hospitals. Individuals with haemoglobin A1c (HbA1c) of 7.0%\u201010.0% after at least 8\u2009weeks of diet and exercise modification were randomized to receive enavogliflozin 0.3\u00a0mg (n\u00a0=\u00a083) or placebo (n\u00a0=\u00a084) for 24\u2009weeks. The primary outcome was a change in HbA1c at week 24 from baseline. Secondary outcomes included the proportion of participants achieving HbA1c &lt;7.0%, change in fasting glucose, body weight and lipid levels. Adverse events were investigated throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 24, the placebo\u2010adjusted mean change in HbA1c from baseline in the enavogliflozin group was \u22120.99% (95% confidence interval \u22121.24%, \u22120.74%). The proportions of patients achieving HbA1c &lt;7.0% (71% vs. 24%) at week 24 was significantly higher in the enavogliflozin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Placebo\u2010adjusted mean changes in fasting plasma glucose (\u221240.1\u00a0mg\/dl) and body weight (\u22122.5\u00a0kg) at week 24 were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). In addition, a significant decrease in blood pressure, low\u2010density lipoprotein cholesterol, triglyceride, and homeostasis model assessment of insulin resistance were observed, along with a significant increase in high\u2010density lipoprotein cholesterol. No significant increase in treatment\u2010related adverse events was observed for enavogliflozin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Monotherapy with enavogliflozin 0.3\u00a0mg improved glycaemic control in people with T2DM. Enavogliflozin therapy also exerted beneficial effects on body weight, blood pressure and lipid profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15046","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T21:24:52Z","timestamp":1678051492000},"page":"1865-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy and safety of enavogliflozin, a novel\n                    <scp>SGLT2<\/scp>\n                    inhibitor, in Korean people with type 2 diabetes: A 24\u2010week, multicentre, randomized, double\u2010blind, placebo\u2010controlled, phase\n                    <scp>III<\/scp>\n                    trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Soo Heon","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-2284","authenticated-orcid":false,"given":"Kyung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CHA Bundang Medical Center CHA University School of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Myung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EunSook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ulsan University Hospital College of Medicine University of Ulsan  Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Chul","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Sanggye Paik Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital  Anyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-7206","authenticated-orcid":false,"given":"Choon Hee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wonju Severance Christian Hospital  Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungjoon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Chang","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University Medical Center  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-3675","authenticated-orcid":false,"given":"Sin Gon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Anam Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-9883","authenticated-orcid":false,"given":"Seung Ah","family":"Cho","sequence":"additional","affiliation":[{"name":"Clinical Development Center Daewoong Pharmaceutical Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-9966","authenticated-orcid":false,"given":"Bo Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Clinical Development Center Daewoong Pharmaceutical Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology Seoul National University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110708"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X15666191111123622"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102015\u2010000154"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010020\u20100406\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16162965"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13648"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30256\u20106"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010020\u201010038\u2010w"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12030268"},{"key":"e_1_2_10_11_1","unstructured":"YangYS MinKW ParkS\u2010O et al.Efficacy and Safety of monotherapy with Enavogliflozin in Korean Patients with Type 2 Diabetes Mellitus: Results of a 14 week multi\u2010center randomized double\u2010blind placebo\u2010controlled phase 2 trial. 2020 International Congress of Diabetes and Metabolism. Korean Diabetes Association. 18\u201019 September 2020.https:\/\/icdm2020.diabetes.or.kr\/program\/oral_list.php"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20100612"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(13)70084\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.11.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12888"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12156"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12054"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u2010S006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0156"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010012\u20100275\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166125"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100958\u20102441"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00590\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217833"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(16)00052\u20108"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12624"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S50773"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.15046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.15046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:25:08Z","timestamp":1761884708000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/dom.15046"],"URL":"https:\/\/doi.org\/10.1111\/dom.15046","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15046\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15046\/v1\/review3","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]},"assertion":[{"value":"2022-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}