{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:23:55Z","timestamp":1784035435851,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy of bexagliflozin in reducing glycated haemoglobin (HbA1c) and the occurrence of side effects in patients with type 2 diabetes (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched the PubMed, Embase, Cochrane and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      databases for placebo\u2010controlled, randomized clinical trials published up until 15 February 2023. The primary outcome was change in HbA1c. We computed weighted mean differences (WMDs) for continuous outcomes and odds ratios (ORs) for binary endpoints, with 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of six studies and 3111 patients were included, of whom 1951 were prescribed bexagliflozin. Compared with placebo, bexagliflozin significantly reduced HbA1c levels (WMD \u20130.53%; 95% CI \u20130.75, \u20130.31), fasting plasma glucose levels (WMD \u20131.45\u2009mmol\/L; 95% CI \u20132.32, \u20130.57), systolic blood pressure (WMD \u20134.66\u2009mmHg; 95% CI \u20136.41, \u20132.92), diastolic blood pressure (WMD \u20132.12\u2009mmHg; 95% CI \u20133.94, \u20130.30), body weight overall (WMD \u20131.61\u2009kg; 95% CI \u20132.14, \u20131.07), and body weight in patients with a body mass index &gt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (WMD \u20132.05\u2009kg; 95% CI \u20132.78, \u20131.31). The proportion of patients who achieved HbA1c\u2009&lt;\u20097% was higher in patients who received bexagliflozin as compared with placebo (OR 1.94; 95% CI 1.36\u20102.78). There were no significant differences between groups regarding side effects such as hypoglycaemia, genital mycotic infection, urinary tract infection, diarrhoea, headache, nausea, polyuria, diabetic ketoacidosis, or all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this meta\u2010analysis, the use of bexagliflozin was associated with improved clinical and laboratory measures in patients with T2DM compared with placebo, with a similar profile of side effects. These findings support the efficacy of bexagliflozin in the treatment of T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15051","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T02:11:15Z","timestamp":1679019075000},"page":"1794-1802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-1162","authenticated-orcid":false,"given":"Eric","family":"Pasqualotto","sequence":"first","affiliation":[{"name":"Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-7795","authenticated-orcid":false,"given":"Janine Midori","family":"Figueiredo Watanabe","sequence":"additional","affiliation":[{"name":"State University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-2445","authenticated-orcid":false,"given":"Douglas Mesadri","family":"Gewehr","sequence":"additional","affiliation":[{"name":"Denton Cooley Institute of Research, Science and Technology  Curitiba Paran\u00e1 Brazil"},{"name":"Curitiba Heart Institute  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-9950","authenticated-orcid":false,"given":"Raphaela","family":"da Silva Maintinguer","sequence":"additional","affiliation":[{"name":"Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-1603","authenticated-orcid":false,"given":"Simone","family":"van de Sande\u2010Lee","sequence":"additional","affiliation":[{"name":"Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Neves","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Institute of Cardiology of Santa Catarina  S\u00e3o Jos\u00e9 Brazil"},{"name":"Imperial Charity Hospital  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-7933","authenticated-orcid":false,"given":"Fidel Silveira","family":"Leal","sequence":"additional","affiliation":[{"name":"Institute of Cardiology of Santa Catarina  S\u00e3o Jos\u00e9 Brazil"},{"name":"Imperial Charity Hospital  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-7266","authenticated-orcid":false,"given":"Carlos Eduardo Andrade","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12307"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000440"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2019.1612879"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2650"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.1959915"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00333549211045838"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_9_14_1","unstructured":"HigginsJPT ThomasJ ChandlerJ et al.Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). 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