{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:17Z","timestamp":1772160137069,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54 GM104940"],"award-info":[{"award-number":["U54 GM104940"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effects of an orlistat mouth rinse on the intake of a high\u2010fat meal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A double\u2010blind, balanced order, crossover study was conducted in participants (n\u2009=\u200910, body mass index 25\u201030\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) assigned to receive placebo or orlistat (24\u2009mg\/mL) prior to a high\u2010fat meal. Participants were divided into low\u2010 or high\u2010fat consumers based on calories consumed from fat following placebo administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The orlistat mouth rinse decreased total and fat calories consumed during the high\u2010fat meal in high\u2010fat consumers, and did not alter calories consumed in low\u2010fat consumers (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Orlistat decreases long\u2010chain fatty acid (LCFA) absorption by inhibiting lipases that breakdown triglycerides. Orlistat mouth rinse decreased fat intake in high\u2010fat consumers, suggesting that orlistat inhibited the detection of LCFAs from the high\u2010fat test meal. Lingual delivery of orlistat is predicted to eliminate the risk of oil incontinence and promote weight loss in individuals who prefer fat.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15101","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T04:10:39Z","timestamp":1683087039000},"page":"2236-2242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orlistat mouth rinse: Using the tongue to deliver antiobesity medication in a double\u2010blind randomized crossover pilot trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Stefany D.","family":"Primeaux","sequence":"first","affiliation":[{"name":"Department of Physiology LSU Health\u2010NO  New Orleans Louisiana USA"},{"name":"Joint Diabetes, Endocrinology &amp; Metabolism Program Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dubin","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Venice Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-6111","authenticated-orcid":false,"given":"Frank L.","family":"Greenway","sequence":"additional","affiliation":[{"name":"Clinical Trials Department Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Gila Therapeutics Inc.Gila Therapeutics. 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