{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:06:18Z","timestamp":1784307978446,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the benefits and harms of drugs approved for weight management in adults with obesity or overweight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed a systematic review of drugs approved for treating obesity and overweight. We searched MEDLINE, Embase and CENTRAL through 26 February 2023. Random\u2010effects network meta\u2010analysis was applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 168 trials (97\u2009938 patients) were included. There was no evidence that drugs approved for weight management had different associations with cardiovascular death (69 trials, 59\u2009037 participants). Naltrexone\/bupropion was associated with lower cardiovascular mortality than placebo (odds ratio [OR], 0.62 [95% CI: 0.39, 0.99]; low certainty evidence). All drugs were associated with greater weight loss at 12\u2009months than placebo (33 trials, 37\u2009616 participants), mainly semaglutide (mean difference [MD], \u22129.02\u2009kg [95% CI: \u221210.42, \u22127.63]; moderate certainty) and phentermine\/topiramate (MD, \u22128.10\u2009kg [95% CI: \u221210.14, \u22126.05]; high certainty); and with greater waist circumference reduction at 12\u2009months than placebo (24 trials, 35\u2009733 participants), mainly semaglutide (MD, \u22127.84\u2009cm [95% CI: \u22129.34, \u22126.34]; moderate certainty) and phentermine\/topiramate (MD, \u22126.20\u2009cm [95% CI: \u22127.46, \u22124.94]; high certainty). Semaglutide and phentermine\/topiramate were associated with lower or no difference in the odds of treatment withdrawal compared with all other drugs (87 trials, 70\u2009860 participants).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adults with obesity or overweight, semaglutide and phentermine\/topiramate were associated with greater body weight loss and waist circumference reduction at 12\u2009months than all other drugs, and lower or no significant difference in risks of withdrawal. There was no evidence that drugs approved for weight management had different associations with cardiovascular death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15138","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T03:55:16Z","timestamp":1685505316000},"page":"2535-2544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical outcomes associated with drugs for obesity and overweight: A systematic review and network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"25","author":[{"given":"Andrea","family":"Iannone","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-2993","authenticated-orcid":false,"given":"Patrizia","family":"Natale","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney Australia"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE\u2010J) University of Bari Aldo Moro  Bari Italy"},{"name":"Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suetonia C.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-6850","authenticated-orcid":false,"given":"Antonio","family":"Nicolucci","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH)  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rendina","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-2678","authenticated-orcid":false,"given":"Francesco","family":"Giorgino","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Laviola","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni F. M.","family":"Strippoli","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney Australia"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE\u2010J) University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Obesity and overweight.https:\/\/wwwwhoint\/news-room\/fact-sheets\/detail\/obesity-and-overweight[Accessed March 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