{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:18:28Z","timestamp":1792181908857,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0013659"],"award-info":[{"award-number":["NNF14OC0013659"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney\u2010PF) in individuals with type 2 diabetes (T2D) and early chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, placebo\u2010controlled study of ezetimibe 10\u2009mg once daily for 16\u2009weeks in individuals with T2D and a UACR of 30\u2009mg\/g or higher was conducted. Kidney\u2010PF was assessed with magnetic resonance spectroscopy. Geometric mean changes from baseline were derived from linear regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 49 participants were randomized to ezetimibe (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). Overall, mean\u2009\u00b1\u2009standard deviation age was 67\u2009\u00b1\u20097\u2009years, body mass index was 31\u2009\u00b1\u20094\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and the proportion of men was 84%. The mean estimated glomerular filtration rate was 76\u2009\u00b1\u200922\u2009mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      and median (first\u2010third quartile) UACR was 95 (41\u2010297) mg\/g. Median kidney\u2010PF was 1.0% (0.3%\u20102.1%). Compared with placebo, ezetimibe did not significantly reduce UACR (mean [95% confidence interval] change: \u22123% [\u221228%\u201031%]) or kidney\u2010PF (mean change: \u221238% [\u221266%\u201014%]). In participants with baseline kidney\u2010PF above the median, ezetimibe reduced kidney\u2010PF significantly (mean change: \u221260% [\u221284%\u2010\u22123%]) compared with placebo, while the reduction in UACR was not significant (mean change: \u221228% [\u221254%\u201015%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ezetimibe did not reduce the UACR or kidney\u2010PF on top of modern T2D management. However, kidney\u2010PF was reduced with ezetimibe in participants with high baseline kidney\u2010PF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15146","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:45:38Z","timestamp":1686174338000},"page":"2605-2615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the effects of ezetimibe on albuminuria and kidney fat in individuals with type 2 diabetes and chronic kidney disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-807X","authenticated-orcid":false,"given":"Niels S\u00f8ndergaard","family":"Heinrich","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune Ploegstra","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Bitsch","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik Bj\u00f8rn","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Haddock","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-0352","authenticated-orcid":false,"given":"Tine Willum","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Fornoni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Katz Family Division of Nephrology and Hypertension University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Bo Wiberg","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-4294","authenticated-orcid":false,"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_9_4_1","unstructured":"FederationID.IDF Diabetes Atlas. 10th edition. 2021 [Accessed 22 March 2022]. 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