{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:37Z","timestamp":1791618937008,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007052","name":"Universit\u00e0 degli Studi di Verona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"Universit\u00e0 degli Studi di Parma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the relationship of genetic variability of adiponectin (\n                      <jats:italic>ADIPOQ<\/jats:italic>\n                      ), leptin (\n                      <jats:italic>LEP<\/jats:italic>\n                      ) and leptin receptor (\n                      <jats:italic>LEPR<\/jats:italic>\n                      ) genes with glucose\u2010insulin system and markers of subclinical atherosclerosis (ATS) in patients with newly diagnosed type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In 794 subjects we performed: 1) euglycemic hyperinsulinemic clamp to assess insulin sensitivity; 2) mathematical modelling of a 5h\u2010OGTT to estimate \u03b2\u2010cell function; 3) resting ECG; 4) carotid artery and lower limb artery eco\u2010doppler sonography to identify ATS; 5) genotyping of tag\u2010SNPs within\n                      <jats:italic>ADIPOQ, LEP<\/jats:italic>\n                      and\n                      <jats:italic>LEPR<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Regression analyses showed: 1) adiponectin levels were negatively associated with BMI, waist\u2010to\u2010hip ratio and triglycerides and positively with HDL and insulin sensitivity (p\u2010all&lt;0.03); 2) leptin levels were positively associated with BMI, HDL\u2010cholesterol and plasma triglycerides and negatively with insulin sensitivity (p\u2010all&lt;0.001). Two SNPs (rs1501299 and rs2241767) within\n                      <jats:italic>ADIPOQ<\/jats:italic>\n                      gene were associated with circulating levels of adiponectin. The ADIPOQ\u2010GAACA haplotype was associated with plasma adiponectin (p=0.034; \u03b2=\u20100.24), ECG abnormalities (p=0.012; OR=2.76), carotid ATS (p=0.025; OR=2.00) and peripheral limb artery ATS (p=0.032; OR=1.90). The LEP\u2010CTA haplotype showed an association with ischemic ECG abnormalities (p=0.017; OR=2.24). Finally, LEPR\u2010GAACGG was associated with circulating leptin (p=0.005; \u03b2=\u20100.31) and worst \u03b2\u2010cell function (p=0.023; \u03b2=\u201015.10). Omnibus haplotype analysis showed that\n                      <jats:italic>ADIPOQ<\/jats:italic>\n                      haplotypes were associated with levels of adiponectin and common carotid artery ATS,\n                      <jats:italic>LEP<\/jats:italic>\n                      with peripheral limb artery ATS, whereas\n                      <jats:italic>LEPR<\/jats:italic>\n                      haplotypes influenced circulating levels of leptin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this study reinforce knowledge on adipokines\u2019 role in regulating glucose metabolism; in particular highlighted the potential atherogenic role of leptin and the anti atherogenic role of adiponectin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15152","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T03:48:24Z","timestamp":1687146504000},"page":"2650-2658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Crosstalk between genetic variability of adiponectin and leptin, glucose\u2010insulin system and subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study 14"],"prefix":"10.1111","volume":"25","author":[{"given":"Chiara","family":"Zusi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Csermely","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-1894","authenticated-orcid":false,"given":"Elisabetta","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Hospital Trust of Verona  Verona 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