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The presence of these co\u2010morbidities substantially increases the risk of morbidity as well as mortality in patients with diabetes. The clinical focus has historically centred around reducing the risk of cardiovascular disease by targeting hyperglycaemia, hyperlipidaemia and hypertension. Nonetheless, patients with type 2 diabetes who have well\u2010controlled blood glucose, blood pressure and lipid levels may still go on to develop heart failure, kidney disease or both. Major diabetes and cardiovascular societies are now recommending the use of treatments such as sodium\u2010glucose co\u2010transporter\u20102 inhibitors and non\u2010steroidal mineralocorticoid receptor antagonists, in addition to currently recommended therapies, to promote cardiorenal protection through alternative pathways as early as possible in individuals with diabetes and cardiorenal manifestations. This review examines the most recent recommendations for managing the risk of cardiorenal progression in patients with type 2 diabetes.<\/jats:p>","DOI":"10.1111\/dom.15181","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T05:55:27Z","timestamp":1688622927000},"page":"2795-2804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Management of the \u2018wicked\u2019 combination of heart failure and chronic kidney disease in the patient with diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-6126","authenticated-orcid":false,"given":"David S. 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