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A PRS increase was associated with increased T1D risk (odds ratio [OR] 2.09, 95% confidence interval [CI]\u20091.72\u20102.55). Moreover, a 1\u2010unit increase in standardized T1D PRS decreased the age at diagnosis by 0.74\u2009years. Combined PRS and human leukocyte antigen (HLA) DQA1*03:02\u2013DQA1*05:01 genotypes could accurately predict T1D risk. In multivariable models, HLA variants and PRS were independent risk factors for T1D risk (OR\u20093.76 [95% CI\u20091.54\u20109.16] and 1.71 [95% CI\u20091.37\u20102.13] for HLA DQA1*03:02\u2013DQA1*05:01 and PRS, respectively). In a limited study population of those aged \u226418\u2009years, PRS remained significantly associated with T1D risk. The association between T1D PRS and age at diagnosis was more obvious among males and patients aged \u226418\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Polygenic risk score and HLA variations enable personalized risk estimates, enhance newborn screening efficiency for ketoacidosis prevention, and addresses the gap in data on T1D prediction in isolated Asian populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15187","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T04:10:36Z","timestamp":1689567036000},"page":"2928-2936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-8844","authenticated-orcid":false,"given":"Wen\u2010Ling","family":"Liao","sequence":"first","affiliation":[{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Center for Personalized Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-1685","authenticated-orcid":false,"given":"Yu\u2010Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Genetics and Metabolism Children's Hospital of China Medical University  Taichung Taiwan"},{"name":"Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate 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