{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:55:08Z","timestamp":1789620908997,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effect of finerenone on the risk of cardiovascular and kidney outcomes in patients with chronic kidney disease and type 2 diabetes, with and without obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A post hoc analysis of the prespecified pooled FIDELITY dataset assessed the association between waist circumference (WC), composite cardiovascular and kidney outcomes, and the effects of finerenone. Participants were stratified by WC risk groups (representing visceral obesity) as low\u2010risk or high\u2013very high\u2010risk (H\u2010\/VH\u2010risk).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 12\u2009986 patients analysed, 90.8% occupied the H\u2010\/VH\u2010risk WC group. Incidence of the composite cardiovascular outcome was similar between finerenone and placebo in the low\u2010risk WC group (hazard ratio [HR] 1.03; 95% confidence interval [CI], 0.72\u20101.47); finerenone reduced the risk in the H\u2010\/VH\u2010risk WC group (HR 0.85; 95% CI, 0.77\u20100.93). For the kidney outcome, the risk was similar in the low\u2010risk WC group (HR 0.98; 95% CI, 0.66\u20101.46) and reduced within the H\u2010\/VH\u2010risk WC group (HR 0.75; 95% CI, 0.65\u20100.87) with finerenone versus placebo. There was no significant heterogeneity between the low\u2010risk and H\u2010\/VH\u2010risk WC groups for cardiovascular and kidney composite outcomes (\n                      <jats:italic>P<\/jats:italic>\n                      interaction\u2009=\u2009.26 and .34, respectively). The apparent greater benefit of finerenone on cardiorenal outcomes but lack of significant heterogeneity observed in H\u2010\/VH\u2010risk WC patients may be because of the small size of the low\u2010risk group. Adverse events were consistent across WC groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In FIDELITY, benefits of finerenone in lowering the risk of cardiovascular and kidney outcomes were not significantly modified by patient obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15197","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T22:59:43Z","timestamp":1688511583000},"page":"2989-2998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The impact of obesity on cardiovascular and kidney outcomes in patients with chronic kidney disease and type 2 diabetes treated with finerenone: Post hoc analysis of the\n                    <scp>FIDELITY<\/scp>\n                    study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-4294","authenticated-orcid":false,"given":"Peter","family":"Rossing","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK) of German Heart Center Charit\u00e9; 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